Evidence map›Paper›PMID 37813821›Full record

ArticleJournal of the American Chemical Society2023

Cryptic Isomerization in Diterpene Biosynthesis and the Restoration of an Evolutionarily Defunct P450.

Zining Li, Baofu Xu, Tyler A Alsup, Xiuting Wei, Wenbo Ning, Daniel G Icenhour, Michelle A Ehrenberger, Ion Ghiviriga, Bao-Doan Giang, Jeffrey D Rudolf

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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  7. Computation-guided scaffold exploration of 2Beilstein journal of organic chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zining LiDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.ORCID 0000-0002-6921-8417
Baofu XuDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.ORCID 0000-0002-0144-2455
Tyler A AlsupDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Xiuting WeiDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Wenbo NingDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Daniel G IcenhourDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Michelle A EhrenbergerDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Ion GhivirigaDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.ORCID 0000-0001-5812-5170
Bao-Doan GiangDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Jeffrey D RudolfDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.ORCID 0000-0003-2718-9651
University of Florida · US

Funding

Discovery and Biosynthesis of Bacterial TerpenoidsR35GM142574 · NIGMS · UNIVERSITY OF FLORIDA · PI Jeffrey Daniel Rudolf · 2021 to 2026
$2.4M
Chemistry-Biology Interface Training Program at the University of FloridaT32GM136583 · NIGMS · UNIVERSITY OF FLORIDA · PI Chenglong Li · 2020 to 2026
$1.1M
Cytochrome P450 Enzymes from Streptomyces: Diverse Biocatalysts in Natural Products BiosynthesisR00GM124461 · NIGMS · UNIVERSITY OF FLORIDA · PI RUDOLF, JEFFREY DANIEL · 2019 to 2021
$747k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIGMS NIH HHS R00 GM124461NIGMS NIH HHS R35 GM142574NIGMS NIH HHS T32 GM136583NIH HHS S10 OD021758
6 · The paper itself

Abstract

Biosynthetic modifications of the 6/10-bicyclic hydrocarbon skeletons of the eunicellane family of diterpenoids are unknown. We explored the biosynthesis of a bacterial

Indexed as

Cytochrome P-450 Enzyme SystemDiterpenesBacteriaIsomerismOxidation-ReductionCytochrome P-450 Enzyme SystemDiterpenes

Identifiers

PMID37813821
PMCPMC11209839
OpenAlexW4387442138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.