ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2024
Personality and Cognition: The Mediating Role of Inflammatory Markers.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Personality nuances and inflammation: A coordinated analysis of six samples.Psychoneuroendocrinology · 2026Pooled it
- Personality and mortality risk: A systematic review and meta-analysis of longitudinal data.Journal of personality and social psychology · 2026Pooled it
- Personality moderates immunological and functional consequences of caregiver burden.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Personality and cognitive resilience to accelerated epigenetic aging.Journal of psychiatric research · 2026Article
- Inhibition of return mediates the relationship between openness to experience and visuospatial ability.PeerJ · 2026Article
- Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Personality nuances and cognition: A multi-cohort and multi-method approach.Journal of psychiatric research · 2025Article
- Personality, Aging, and Alzheimer's Disease: Implications for Psychoneuroimmunology and Personalized Medicine.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The mediational role of hearing acuity in the association between personality and memory: Evidence from the health and retirement study and the English Longitudinal Study of Ageing.Journal of psychosomatic research · 2024Article
- Personality nuances and risk of dementia: Evidence from two longitudinal studies.Journal of psychiatric research · 2024Article
- Longitudinal Associations between Personality Traits and Cognitive Complaints in Midlife and Older Age Across 20 Years.European journal of personalityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
objectivesFive-Factor Model personality traits are associated consistently with cognition. Inflammation has been hypothesized as a biological pathway in this association, but this assumption has yet to be tested. The present study tested inflammatory markers as mediators between personality traits and cognition.
methodsParticipants were from the Health and Retirement Study (HRS; N = 4,364; 60% women; mean age = 64.48 years, standard deviation = 8.79). Personality traits and demographic factors were assessed in 2010/2012. Data on inflammatory markers (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL-6], soluble tumor necrosis factor 1 (sTNFR1), interleukin-10 [IL-10], interleukin-1 receptor antagonist [IL-1Ra], and transforming growth factor [TGF]-β1) were obtained in 2016 from the HRS Venuous Blood Study. Cognition was assessed in 2020 using the modified Telephone Interview for Cognitive Status.
resultsHigher neuroticism was related to lower cognition at follow-up, whereas higher extraversion, openness, agreeableness, and conscientiousness were associated with better cognition. Higher extraversion and higher conscientiousness were related to lower hsCRP, IL-6, IL-10, IL-1Ra, and sTNFR1, and higher openness was associated with lower IL-10, IL-1Ra, and sTNFR1 and to higher soluble TGF-β1. Lower sTNFR1 partially mediated the associations between conscientiousness, extraversion, and openness and cognition at follow-up, explaining an estimated 4%-12% of these associations. The mediating role of sTNFR1 persisted when physical activity and depressive symptoms were included as additional mediators. DISCUSSION: The present study provides new evidence on personality and inflammatory markers. Consistent with the inflammation hypothesis, the sTNFR1 finding supports a potential biological pathway between personality and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.