Evidence map›Paper›PMID 37813571›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Quantifying Peripheral Modulation of Olfaction by Trigeminal Agonists.

Federica Genovese, Jiang Xu, Marco Tizzano, Johannes Reisert

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Ex Vivo Multisite Electro-olfactogram Recordings in Rabbit Neonates.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Federica GenoveseMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104 fgenovese@monell.org.ORCID 0000-0003-3762-4776
Jiang XuMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104.
Marco TizzanoMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104.ORCID 0000-0001-9797-0676
Johannes ReisertMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104.ORCID 0000-0002-9393-9257
Monell Chemical Senses Center · US

Funding

The role of solitary chemosensory cells in periodontal homeostasisR01DE028979 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI TIZZANO, MARCO · 2020 to 2024
$2.6M
Role of solitary chemosensory cells in irritant avoidance and protection of olfactory sensationR01DC016598 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI TIZZANO, MARCO · 2017 to 2021
$1.9M
The roles and functions of olfactory transduction channels in the odorant responseR01DC016647 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI REISERT, JOHANNES, WANG, HONG · 2018 to 2022
$1.7M
Trigeminal Modulation of Olfactory Responses in the Main Olfactory EpitheliumR21DC018358 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI GENOVESE, FEDERICA · 2020 to 2022
$465k
Nasal solitary chemosensory cells linking irritation to inflammationR03DC012413 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI TIZZANO, MARCO · 2012 to 2014
$445k
NIDCD NIH HHS R01 DC016598NIDCD NIH HHS R01 DC016647NIDCD NIH HHS R03 DC012413NIDCD NIH HHS R21 DC018358NIDCR NIH HHS R01 DE028979
6 · The paper itself

Abstract

In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the olfactory system as well. Although these two systems constitute two separate sensory modalities, trigeminal activation modulates the neural representation of an odor. The mechanisms behind the modulation of olfactory response by trigeminal activation are still poorly understood. We addressed this question by looking at the olfactory epithelium (OE), where olfactory sensory neurons (OSNs) and trigeminal sensory fibers co-localize and where the olfactory signal is generated. Our study was conducted in a mouse model. Both sexes, males and females, were included. We characterize the trigeminal activation in response to five different odorants by measuring intracellular Ca

Indexed as

Olfactory Receptor NeuronsPhenylethyl AlcoholAnimalsFemaleHumansMaleMammalsMiceMice, KnockoutOdorantsOlfactory MucosaSmellPhenylethyl Alcoholchemesthesischemosensoryolfactionphysiology

Identifiers

PMID37813571
PMCPMC10669757
OpenAlexW4387450302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.