Evidence map›Paper›PMID 37813563›Full record

ArticleeNeuro2023

Neuronal Activity Changes the Number of Neurons That Are Synaptically Connected to OPCs.

Daniela Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Jesse Garcia, Emma Brennan, Robert Brock, Iris Tilton, Lindsay Halladay, Samuel Pleasure and 1 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Daniela MouraBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Alekhya ParvathaneniBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Atehsa SahagunBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Hirofumi NoguchiNeurology Department, University of California, San Francisco, San Francisco, CA 94110.
Jesse GarciaNeurology Department, University of California, San Francisco, San Francisco, CA 94110.
Emma BrennanBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Robert BrockBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Iris TiltonBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.
Lindsay HalladayBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053.ORCID 0000-0003-2232-6709
Samuel PleasureNeurology Department, University of California, San Francisco, San Francisco, CA 94110.ORCID 0000-0001-8599-1613
Laura CocasBiology Department, Neuroscience Program, Santa Clara University, Santa Clara, CA 95053 lcocas@scu.edu.
Society for Neuroscience · USUniversity of California, San Francisco · US

Funding

NeuroCovid Autoantibodies: Establishing a research pipelineR01NS118995 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PLEASURE, SAMUEL JEREMY · 2020 to 2024
$2.3M
Wnt Signaling in Hippocampal &Neocortical DevelopmentR01MH066084 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PLEASURE, SAMUEL JEREMY · 2003 to 2007
$1.6M
The Role of Neuroligin Synaptic Adhesion Proteins on Oligodendrocyte Development and Myelination.R15NS108234 · NINDS · SANTA CLARA UNIVERSITY · PI Laura A Cocas · 2018 to 2026
$924k
NIMH NIH HHS R01 MH066084NINDS NIH HHS R01 NS118995NINDS NIH HHS R15 NS108234
6 · The paper itself

Abstract

The timing and specificity of oligodendrocyte myelination during development, as well as remyelination after injury or immune attack, remain poorly understood. Recent work has shown that oligodendrocyte progenitors receive synapses from neurons, providing a potential mechanism for neuronal-glial communication. In this study, we investigated the importance of these neuroglial connections in myelination during development and during neuronal plasticity in the mouse hippocampus. We used chemogenetic tools and viral monosynaptic circuit tracing to analyze these connections and to examine oligodendrocyte progenitor cells (OPCs) proliferation, myelination, synapse formation, and neuronal-glial connectivity

Indexed as

Oligodendrocyte Precursor CellsAnimalsCell DifferentiationMiceNeurogenesisNeurogliaNeuronsOligodendrogliaactivity-dependent developmentconnectivitygliogenesisneural glial interactionssynapse formation

Identifiers

PMID37813563
PMCPMC10598642
OpenAlexW4387450185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.