ArticleOccupational and environmental medicine2023
Shiftwork, long working hours and markers of inflammation in a national US population-based sample of employed black and white men and women aged ≥45 years.
Article in Occupational and environmental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Body mass index links night work intensity with higher low-grade systemic inflammation: results from a field study in humans.International archives of occupational and environmental health · 2026Article
- Circadian gatekeepers of the gut-brain-immune axis: implications for neuroinflammation and neurodegeneration.Journal of neuroinflammation · 2026Review
- Investigating the Risk of Obesity in European Night Shift Workers: A Study Protocol for Cross-Sectional and Mechanistic Studies in the SHIFT2HEALTH Project.Obesity facts · 2026Article
- Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time.Life metabolism · 2025Review
- The association between irregular working hours and cardiovascular diseases in a multi-ethnic population: the HELIUS study.Occupational medicine (Oxford, England) · 2025Observational
- Risk for Diabetes From Long Working Hours and Night Work in the United States: Prospective Associations and Machine Learning Techniques.Safety and health at work · 2025Article
- Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Article
- Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses.International journal of molecular sciences · 2025Article
- The Association Between Air Pollution Exposure and White Blood Cell Counts: A Nationwide Cross-Sectional Survey in South Korea.Journal of clinical medicine · 2024Article
- Adverse Associations of Long-Term Exposure to PMToxics · 2024Article
- Human immune and metabolic biomarker levels, and stress-biomarker associations, differ by season: Implications for biomedical health research.Brain, behavior, & immunity - health · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesWork schedule demands contribute to circadian disruption and may influence health via an inflammatory response. We examined the impact of shiftwork and long work hours on inflammation in a national US sample.
methodsParticipants included 12 487 employed black and white men and women aged ≥45 years enrolled in the REasons for Geographic and Racial Differences in Stroke Study who completed an occupational questionnaire (2011-2013) and clinical examination (2013-2016). Cross-sectional associations between shiftwork and work hours with log-transformed high-sensitivity C reactive protein (CRP) and white blood cell (WBC) count were examined by multiple linear regression analysis, overall and by race-sex subgroups.
resultsOverall, rotating shift workers had higher log-CRP concentration compared with day workers (β=0.09, 95% CI:0.02 to 0.16) and findings for WBC were null. Black women had the highest geometric mean CRP (2.82 mg/L), while white men had the highest WBC (6.35×10
conclusionsShift workers had higher inflammatory markers compared with day workers and race-sex disparities should be examined further. These findings highlight a potential biological pathway linking work schedule demands and chronic disease.
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Registered trials
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