ArticleEpilepsia open2023
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms.
Article in Epilepsia open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 5 citations in OpenAlex.
- Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies.Epilepsia open · 2026Article
- The impact of seizures on REM sleep and the cholinergic pedunculopontine nucleus in a mouse model of Dravet Syndrome.bioRxiv : the preprint server for biology · 2026Article
- Alterations in serum metabolomics predict drug-resistant epilepsy.Scientific reports · 2025Article
- Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy.Epilepsia open · 2024Article
- An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms.Epilepsia open · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveEpilepsy and depression share neurobiological origins, and evidence suggests a possible bidirectional relationship that remains poorly understood. This exploratory, cross-sectional study aimed to investigate this relationship by employing magnetic resonance spectroscopic imaging (MRSI) and thermometry (MRSI-t) in patients with temporal lobe epilepsy (TLE) with comorbid depressive symptoms and control participants. This is the first study to combine MRSI and MRSI-t to examine brain temperature and choline abnormalities in regions implicated in seizure onset and depression.
methodsTwenty-six patients with TLE and 26 controls completed questionnaires and underwent imaging at 3T. Volumetric echo-planar MRSI/MRSI-t data were processed within the Metabolite Imaging and Data Analysis System (MIDAS). Choline (CHO) was quantified as a ratio over creatine (CRE; CHO/CRE). Brain temperature (T
resultsCompared to controls, patients with TLE reported more depressive symptoms (P = 0.04) and showed CHO/CRE and T SIGNIFICANCE: Abnormalities in T
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