Evidence map›Paper›PMID 37813137›Full record

ArticleEnvironmental research2023

Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months.

Rachel L Miller, Janelle Rivera, Lydia Lichtiger, Usha S Govindarajulu, Kyung Hwa Jung, Stephanie Lovinsky-Desir, Frederica Perera, Susan Balcer Whaley, Michelle Newman, Torie L Grant and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Wildfire and asthma - The prospective interventions.The World Allergy Organization journal · 2025
    Review
  4. Review
  5. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Rachel L MillerDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA; Columbia Center for Childrens Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY, 10032, USA. Electronic address: Rachel.miller2@mssm.edu.
Janelle RiveraDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Lydia LichtigerDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Usha S GovindarajuluCenter for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Kyung Hwa JungDivision of Pediatric Pulmonary, Columbia University Irving Medical Center, 630 W. 168th St, New York, NY, 10032, USA.
Stephanie Lovinsky-DesirDivision of Pediatric Pulmonary, Columbia University Irving Medical Center, 630 W. 168th St, New York, NY, 10032, USA.
Frederica PereraColumbia Center for Childrens Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY, 10032, USA.
Susan Balcer WhaleyDepartment of Population Health, Dell Medical School University of Texas at Austin, 1601 Trinity St., Bldg. B, Stop Z0500, Austin, TX, 78712, USA.
Michelle NewmanDepartment of Epidemiology and Public Health, University of Maryland, 10 S. Pine St, MSTF 3-34, Baltimore, MD, 21201, USA.
Torie L GrantDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Meredith McCormackDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthew PerzanowskiColumbia Center for Childrens Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY, 10032, USA.
Elizabeth C MatsuiDepartment of Population Health, Dell Medical School University of Texas at Austin, 1601 Trinity St., Bldg. B, Stop Z0500, Austin, TX, 78712, USA.
Center for Children · USIcahn School of Medicine at Mount Sinai · USColumbia University Irving Medical Center · USJohns Hopkins University · USThe University of Texas at Austin · USUniversity of Maryland, Baltimore · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority childrenR01ES026170 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI KEET, CORINNE, MATSUI, ELIZABETH C. · 2016 to 2025
$6.8M
Urban Diesel Exposure and Inner City AsthmaR01ES013163 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, RACHEL L · 2005 to 2016
$6.5M
Environmental Control as Add-on Therapy in Urban Children with AsthmaR01ES023447 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2014 to 2018
$3.4M
Urban planning, siting of air pollution sources, and asthma disparitiesR01ES034803 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI Elizabeth C. Matsui, ROGER PENG · 2023 to 2026
$2.1M
Mentoring in Patient-Oriented Research on Asthma and the Indoor EnvironmentK24AI114769 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, ELIZABETH C. · 2015 to 2023
$1.6M
Allergen Exposure Reduction as a Disease-Modifying Strategy in Allergen-Sensitized Children with AsthmaK23AI159144 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRANT, TORIE · 2021 to 2025
$991k
Mitochondrial DNA biomarkers to assess responses to changes in personal environmental exposures in pediatric urban asthmaR21ES029607 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MILLER, RACHEL L · 2019 to 2020
$465k
NCATS NIH HHS UL1 TR004419NIAID NIH HHS K23 AI159144NIAID NIH HHS K24 AI114769NIEHS NIH HHS R01 ES013163NIEHS NIH HHS R01 ES023447NIEHS NIH HHS R01 ES026170NIEHS NIH HHS R01 ES034803NIEHS NIH HHS R21 ES029607
6 · The paper itself

Abstract

Determining biomarkers of responses to environmental exposures and evaluating whether they predict respiratory outcomes may help optimize environmental and medical approaches to childhood asthma. Relative mitochondrial (mt) DNA abundance and other potential mitochondrial indicators of oxidative stress may provide a sensitive metric of the child's shifting molecular responses to its changing environment. We leveraged two urban childhood cohorts (Environmental Control as Add-on Therapy in Childhood Asthma (ECATCh); Columbia Center for Children's Environmental Health (CCCEH)) to ascertain whether biomarkers in buccal mtDNA associate with airway inflammation and altered lung function over 6 months of time and capture biologic responses to multiple external stressors such as indoor allergens and fine particulate matter (PM

Indexed as

AsthmaMouth MucosaAnimalsBiomarkersChildDNA, MitochondrialHumansMiceParticulate MatterProspective StudiesBiomarkersDNA, MitochondrialParticulate MatterMitochondrial biomarkersUrban asthma

Identifiers

PMID37813137
PMCPMC10843300
OpenAlexW4387472256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.