Evidence map›Paper›PMID 37812712›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a

Sean B Romanowski, Sanghoon Lee, Sylvia Kunakom, Bruno S Paulo, Michael J J Recchia, Dennis Y Liu, Hannah Cavanagh, Roger G Linington, Alessandra S Eustáquio

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  9. Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from aProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sean B Romanowski *Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607.
Sanghoon Lee *Department of Chemistry, Simon Fraser University, Burnaby, BC V5H 1S6, Canada.
Sylvia Kunakom *Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607.
Bruno S PauloDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-1521-5034
Michael J J RecchiaDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5H 1S6, Canada.ORCID 0000-0002-1450-0941
Dennis Y LiuDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5H 1S6, Canada.
Hannah CavanaghDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5H 1S6, Canada.
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5H 1S6, Canada.ORCID 0000-0003-1818-4971
Alessandra S EustáquioDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-7852-7844
Simon Fraser University · CAUniversity of Illinois Chicago · US

Funding

Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
Development of a Bacterial Host for Natural Product Discovery and ProductionR01GM129344 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI EUSTAQUIO, ALESSANDRA S · 2020 to 2023
$1.5M
NCCIH NIH HHS T32 AT007533NIGMS NIH HHS R01 GM129344
6 · The paper itself

Abstract

Bacterial natural products have found many important industrial applications. Yet traditional discovery pipelines often prioritize individual natural product families despite the presence of multiple natural product biosynthetic gene clusters in each bacterial genome. Systematic characterization of talented strains is a means to expand the known natural product space. Here, we report genomics, epigenomics, and metabolomics studies of

Indexed as

Biological ProductsBurkholderiaDNAHumansLipopeptidesMultigene FamilyPeptide SynthasesSerineBiological ProductsDNALipopeptidesnon-ribosomal peptide synthasePeptide SynthasesSerinebacterial host developmentlipopeptidenatural products

Identifiers

PMID37812712
PMCPMC10589681
OpenAlexW4387448736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.