Evidence map›Paper›PMID 37812688›Full record

ArticleACS sensors2023

Texaphyrin-Based Calcium Sensor for Multimodal Imaging.

Grégory D Thiabaud, Miriam Schwalm, Sajal Sen, Ali Barandov, Jacob Simon, Peter Harvey, Virginia Spanoudaki, Peter Müller, Jonathan L Sessler, Alan Jasanoff

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. A molecular probe for detecting cholinesterase activity in MRI.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Role of mitochondrial CaMolecular medicine reports · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Grégory D ThiabaudDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-5189-8445
Miriam SchwalmDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.
Sajal SenDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-1189-4156
Ali BarandovDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.
Jacob SimonDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.
Peter HarveyDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-5159-5313
Virginia SpanoudakiPreclinical Imaging & Testing Facility, Koch Institute at MIT, 77 Massachusetts Ave. Rm. 76-188, Cambridge, Massachusetts 02139, United States.
Peter MüllerDepartment of Chemistry, X-ray Diffraction Facility, 77 Massachusetts Ave. Rm 2-325, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-6530-3852
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, United States.ORCID 0000-0002-9576-1325
Alan JasanoffDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Rm. 16-561, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-2834-6359
Massachusetts Institute of Technology · USThe University of Texas at Austin · US

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
Genetically-targeted hemodynamic functional imagingU01NS103470 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2017 to 2019
$1.6M
Nanosensors for sensitive brain-wide neurochemical imagingR01NS120592 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2021 to 2021
$1.4M
Supplement to Neurobiological Engineering Training ProgramT32EB019940 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2015 to 2025
$1.4M
Multimodal probes for multiscale calcium imagingR21EY032369 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2021 to 2022
$464k
NCI NIH HHS R01 CA068682NEI NIH HHS R21 EY032369NIBIB NIH HHS T32 EB019940NINDS NIH HHS R01 NS120592NINDS NIH HHS U01 NS103470Wellcome Trust
6 · The paper itself

Abstract

The ability to monitor intracellular calcium concentrations using fluorescent probes has led to important insights into biological signaling processes at the cellular level. An important challenge is to relate such measurements to broader patterns of signaling across fields of view that are inaccessible to optical techniques. To meet this need, we synthesized molecular probes that couple calcium-binding moieties to lanthanide texaphyrins, resulting in complexes endowed with a diverse complement of magnetic and photophysical properties. We show that the probes permit intracellular calcium levels to be assessed by fluorescence, photoacoustic, and magnetic resonance imaging modalities and that they are detectable by multimodal imaging in brain tissue. This work thus establishes a route for monitoring signaling processes over a range of spatial and temporal scales.

Indexed as

CalciumPorphyrinsMagnetic Resonance ImagingMultimodal ImagingCalciumPorphyrinstexaphyrincalciumcellular signalingmolecular imagingsensortexaphyrin

Identifiers

PMID37812688
PMCPMC11000421
OpenAlexW4387448682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.