ArticleIntensive care medicine2023
Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU).
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Article in Intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 1 of them a synthesis that pooled it.
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49citing papers in PubMed, 1 pooled it
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49 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Guideline
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- ICU Clinicians' View on Platelet Transfusion Thresholds for a Future Trial-Protocol for an International Survey.Acta anaesthesiologica Scandinavica · 2026Article
- Prognostic value of the early D-dimer/fibrinogen ratio in critically ill patients requiring vascular surgery: a retrospective study.BMC anesthesiology · 2026Article
- Prediction model for quality of life in sepsis survivors one year after discharge.World journal of emergency medicine · 2026Article
- Sepsis induced coagulopathy (SIC): is it monolithic?Thrombosis journal · 2026Article
- Dynamic thrombocytopenia following cardiac arrest is associated with systemic inflammation and predicts increased mortality.BMC emergency medicine · 2026Article
- Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit.Vox sanguinis · 2026Observational
- Coefficient of variation of platelet count as a prognostic Indicator for intracerebral hemorrhage: findings from a multicenter cohort.Frontiers in neurology · 2026Article
- Clinical Characteristics and Outcomes of Carbapenem-Resistant Gram-Negative Bacteria Pneumonia in Immunocompromised ICU Patients: A Retrospective Study.Infection and drug resistance · 2026Article
- From vital sign trajectories to data-driven targets: defining exploratory blood gas ranges in sepsis-associated thrombocytopenia.Frontiers in medicine · 2026Article
- Prevalence, Risk Factors, Characteristics, and Clinical Outcomes of Thrombocytopenia in the Intensive Care Unit: A Prospective Single-Center Cohort Study.Critical care research and practice · 2026Article
- Optimizing platelet transfusion thresholds based on TEG maximum clot strength (MA value) to reduce platelet usage and improve patient outcomes in liver transplantation: a cohort study.Frontiers in medicine · 2026Article
- Dynamic platelet profiles in the emergency department and their predictive value for 28-day all-cause mortality in septic patients.PloS one · 2026Article
- Whole transcriptome analysis reveals T cell signaling activation in septic patients with thrombocytopenia.Scientific reports · 2025Article
- Postoperative Thrombocytopenia in Cardiac Surgery: Patterns, Differential Diagnosis and Management of Heparin-Induced Thrombocytopenia (HIT).Journal of clinical medicine · 2025Review
- Platelet transfusion response in critically ill patients with thrombocytopenia: a retrospective study and predictive nomogram in a general ICU population.Annals of medicine · 2025Article
- Hemostasis disorders: from bleeding to thrombosis.Intensive care medicine · 2025Article
- Association of platelet trajectory patterns with in-hospital mortality in critically ill adults with acute kidney injury receiving continuous renal replacement therapy.BMC nephrology · 2025Article
- Postresuscitation platelet transfusion in major trauma patients.Transfusion · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
56 authors at 20 institutions in 10 countries.
Carl Thomas AnthonDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7740-700X
Frédéric PèneMédecine Intensive and Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0003-3639-3849
Anders PernerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4668-0123
Elie AzoulayMédecine Intensive and Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-8162-1508
Kathryn PuxtyDepartment of Intensive Care, Glasgow Royal Infirmary, Glasgow, UK.ORCID http://orcid.org/0000-0002-5742-6171
Andry Van De LouwDivision of Pulmonary and Critical Care, Penn State University College of Medicine, Hershey, PA, USA.
Andreas Barratt-DueDepartment of Anaesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Rikshospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0001-5408-7162
Sanjay ChawlaCritical Care Medicine Service, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6840-7988
Pedro CastroMedical Intensive Care Unit, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6118-8970
Pedro PóvoaDepartment of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-7069-7304
Luis CoelhoDepartment of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-0701-3624
Victoria MetaxaDepartment of Critical Care, King's College Hospital NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-4232-6845
Matthias KochanekDepartment I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-4766-4651
Tobias LiebregtsDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Thomas KanderDepartment of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden.ORCID http://orcid.org/0000-0002-5404-2981
Johanna HästbackaDepartment of Perioperative and Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3613-7231
Jo Bønding AndreasenDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-6615-4438
Edwige PéjuMédecine Intensive and Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0001-7356-7858
Lene Bjerregaard NielsenDepartment of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.ORCID http://orcid.org/0000-0003-0826-4126
Christine Lodberg HvasDepartment of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Etienne DufrancService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID http://orcid.org/0009-0007-3878-708X
Emmanuel CanetMédecine Intensive Réanimation, CHU de Nantes, Université de Nantes, Nantes, France.ORCID http://orcid.org/0000-0002-2143-8082
Linda LundqvistDepartment of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden.
Christopher John WrightCritical Care Unit, Elizabeth University Hospital, Glasgow, Queen, UK.
Julien SchmidtService de Réanimation Médico-Chirurgicale, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID http://orcid.org/0000-0003-3034-6857
Fabrice UhelMédecine Intensive Réanimation, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, DMU ESPRIT, Paris, France.ORCID http://orcid.org/0000-0003-4946-8184
Hafid Ait-OufellaService de Médecine Intensive-Réanimation, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-2955-0183
Mette KragDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5246-8727
Elisabet Cos BadiaDepartment of Intensive Care, Hospital General Granollers, Barcelona, Spain.
Cándido Díaz-LagaresIntensive Care Department, Vall d'Hebron Hospital Universitari, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3046-7598
Sophie MenatService de Médecine Intensive-Réanimation, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Guillaume VoiriotService de Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Centre de Recherche Saint-Antoine UMRS_938 INSERM, Paris, France.ORCID http://orcid.org/0000-0003-2236-0288
Niels Erikstrup ClausenDepartment of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4370-859X
Kristian LorentzenDepartment of Intensive Care, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Reidar KvåleDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0001-8839-6131
Thomas HildebrandtDepartment of Intensive Care, Zealand University Hospital - Roskilde, Roskilde, Denmark.ORCID http://orcid.org/0000-0001-7845-9899
Aleksander Rygh HoltenDepartment of Acute Medicine, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-7916-0717
Kristian StrandDepartment of Intensive Care, Stavanger University Hospital, Stavanger, Norway.ORCID http://orcid.org/0000-0002-1522-0941
Asterios TzalavrasDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-1650-0048
Morten Heiberg BestleDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6585-2659
Pål KlepstadDepartment of Intensive Care Medicine, St. Olav's University Hospital, Trondheim, Norway.ORCID http://orcid.org/0000-0003-2804-8447
Sara FernandezMedical Intensive Care Unit, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2912-3357
Damien VimpereMédecine Intensive and Réanimation, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
Carolina PaulinoNova Medical School, CHRC, New University of Lisbon, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-5870-9544
Carina GraçaDepartment of Intensive Care, Hospital Central do Funchal, Funchal, Portugal.ORCID http://orcid.org/0000-0001-6968-0903
Catherina LueckDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-9597-6142
Christian Svendsen JuhlDepartment of Anaesthesiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.ORCID http://orcid.org/0000-0001-7869-6536
Carolina CostaIntensive Care Unit, Hospital Professor Doutor Fernando Fonseca, EPE, Amadora, Portugal.
Per Martin BådstøløkkenDepartment of Intensive Care B203, Akershus University Hospital, Lorenskog, Norway.
Teresa MirandaDepartment of Intensive Care, Sao Francisco Xavier Hospital, CHLO, Lisbon, Portugal.
Lia Susana Aires LêdoDepartment of Intensive Care Medicine-Unit 2, Hospital Egas Moniz-CHLO, EPE, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-1462-4263
Joao Carlos Sousa TorresDepartment of Intensive Care Medicine-Unit 1, Hospital Egas Moniz-CHLO, EPE, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-3170-3692
Anders GranholmDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5799-7655
Morten Hylander MøllerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6378-9673
Lene RussellDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. lene.russell@mail.dk.ORCID http://orcid.org/0000-0001-7352-8728
on behalf of the PLOT-ICU Collaborators and the Nine-I Study Group
Centre Hospitalier Universitaire de Nantes · FRUniversité Paris Cité · FRKing's College Hospital NHS Foundation Trust · GBUniversity of Helsinki · FIMemorial Sloan Kettering Cancer Center · USUniversity of Copenhagen · DKAalborg University Hospital · DKHospital Prof. Dr. Fernando Fonseca · PTOslo University Hospital · NOSorbonne Université · FRAkershus University Hospital · NOCentre National de la Recherche Scientifique · FRCopenhagen University Hospital · DKGlasgow Royal Infirmary · GBHospital de Egas Moniz · PTUniversity of Lisbon · PTAarhus University Hospital · DKAssistance Publique – Hôpitaux de Paris · FRMedizinische Hochschule Hannover · DEUniversity of Duisburg-Essen · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
purposeThrombocytopenia (platelet count < 150 × 10
methodsWe conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.
resultsWe analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).
conclusionThrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
Indexed as
Platelet TransfusionThrombocytopeniaAdultCohort StudiesFemaleHemorrhageHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesRetrospective StudiesBleedingCritical illnessIntensive care unitPlatelet transfusionThrombocytopeniaThrombosis
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