Evidence map›Paper›PMID 37812184›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2024

Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.

Chao Xie, Youliang Ren, Jason Weeks, Joshua Rainbolt, Howard M Kenney, Thomas Xue, Faith Allen, Ye Shu, Allie J H Tay, Sashank Lekkala and 7 more

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Osteomyelitis.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Bisphosphonate-Conjugated Sitafloxacin for Treatment ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chao XieCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-6197-2506
Youliang RenCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Jason WeeksCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Joshua RainboltCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Howard M KenneyCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Thomas XueCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Faith AllenCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Ye ShuCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Allie J H TayCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Sashank LekkalaCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-6638-9029
Shu-Chi A YehCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.
Gowrishankar MuthukrishnanCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-7521-6154
Ann L GillDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Steven R GillDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Minsoo KimDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Stephen L KatesDepartment of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Edward M SchwarzCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-4854-9698

Funding

University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2017 to 2026
$13.6M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Diagnosis and Tracking of Spinal Staphylococcus aureus Orthopaedic Implant InfectionsR21AI169736 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ACKERT-BICKNELL, CHERYL LYNNE, MUTHUKRISHNAN, GOWRISHANKAR · 2022 to 2023
$439k
Quantifying the Race for the Surface via IV-MLSMR21AR081050 · NIAMS · UNIVERSITY OF ROCHESTER · PI SCHWARZ, EDWARD M., XIE, CHAO · 2022 to 2023
$373k
Elucidating the Mechanisms of Lymphatic Muscle Cell Dysfunction in Aging and InflammationF30AG076326 · NIA · UNIVERSITY OF ROCHESTER · PI KENNEY, HOWARD MARK · 2022 to 2023
$98k
NIAID NIH HHS R21 AI169736NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P50 AR072000NIAMS NIH HHS R21 AR081050NIA NIH HHS F30 AG076326NIGMS NIH HHS T32 GM007356NIH HHS F30 AG076326NIH HHS P30 AR069655NIH HHS P50 AR072000NIH HHS R21 AI169736NIH HHS R21 AR081050NIH HHS T32 GM007356
6 · The paper itself

Abstract

Critical knowledge gaps of orthopedic infections pertain to bacterial colonization. The established dogma termed the Race for the Surface posits that contaminating bacteria compete with host cells for the implant post-op, which remains unproven without real-time in vivo evidence. Thus, we modified the murine longitudinal intravital imaging of the bone marrow (LIMB) system to allow real-time quantification of green fluorescent protein (GFP+) host cells and enhanced cyan fluorescent protein (ECFP+) or red fluorescent protein (RFP+) methicillin-resistant Staphylococcus aureus (MRSA) proximal to a transfemoral implant. Following inoculation with ~10

Indexed as

Methicillin-Resistant Staphylococcus aureusOsteomyelitisStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsBone MarrowCross-Sectional StudiesDisease Models, AnimalMiceAnti-Bacterial Agentshost immunityintravital imagingMRSAosteomyelitisRace for the Surface

Identifiers

PMID37812184
PMCPMC10932844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.