Evidence map›Paper›PMID 37811979›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Association of cancer history with structural brain aging markers of Alzheimer's disease and related dementias risk.

Jingxuan Wang, Kendra D Sims, Sarah F Ackley, Ruijia Chen, Lindsay C Kobayashi, Eleanor Hayes-Larson, Elizabeth Rose Mayeda, Peter Buto, Scott C Zimmerman, Rebecca E Graff and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jingxuan WangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Kendra D SimsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Sarah F AckleyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Ruijia ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Lindsay C KobayashiDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Eleanor Hayes-LarsonDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.
Peter ButoDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Scott C ZimmermanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · US

Funding

Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
Translational Epidemiology - Training for Research on Aging and Chronic diseaseT32AG049663 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Rose Mayeda, Mark J Pletcher · 2016 to 2026
$5.8M
The inverse association between cancer and Alzheimers disease: comparing spurious and causal explanations to illuminate the causes of Alzheimers diseaseRF1AG059872 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLYMOUR, MEDELLENA MARIA · 2018 to 2021
$1.9M
Mathematical Models of Tau-PET Measures and Cognitive Decline in Alzheimer’s Disease Across the LifespanK99AG073454 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ACKLEY, SARAH · 2022 to 2024
$250k
Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkersK99AG075317 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAYES-LARSON, ELEANOR LOUISE · 2022 to 2023
$241k
NIA NIH HHS K99 AG073454NIA NIH HHS K99AG073454NIA NIH HHS K99 AG075317NIA NIH HHS K99AG075317NIA NIH HHS RF1 AG059872NIA NIH HHS RF1AG059872NIA NIH HHS T32 AG049663NIA NIH HHS T32AG049663NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

introductionCancer survivors are less likely than comparably aged individuals without a cancer history to develop Alzheimer's disease and related dementias (ADRD).

methodsIn the UK Biobank, we investigated associations between cancer history and five structural magnetic resonance imaging (MRI) markers for ADRD risk, using linear mixed-effects models to assess differences in mean values and quantile regression to examine whether associations varied across the distribution of MRI markers.

resultsCancer history was associated with smaller mean hippocampal volume (b = -19 mm DISCUSSION: Some brain MRI markers associated with ADRD risk were elevated in adults with a history of cancer. The magnitude of the adverse associations varied across quantiles of neuroimaging markers, and the pattern suggests possible harmful associations for individuals already at high ADRD risk. HIGHLIGHTS: We found no evidence of an inverse association between cancer history and ADRD-related neurodegeneration. Cancer history was associated with smaller mean hippocampal volume and lower mean cortical thickness in the Alzheimer's disease signature region. Quantile regressions indicated individuals most vulnerable to ADRD were more affected by cancer history.

Indexed as

Alzheimer DiseaseDementiaNeoplasmsAgedAgingBrainHumansMagnetic Resonance ImagingAlzheimer's disease and related dementiascancerneuroimagingquantile regression

Identifiers

PMID37811979
PMCPMC10916958
OpenAlexW4387439357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.