SynthesisJournal of psychopharmacology (Oxford, England)2023
Dopamine in major depressive disorder: A systematic review and meta-analysis of in vivo imaging studies.
Synthesis in Journal of psychopharmacology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Cortical 5-HTMolecular psychiatry · 2025Pooled it
- The Association Between Delayed Sleep-Wake Phase Disorder and Depression Among Young Individuals: A Systematic Review and Meta-Analysis: Association entre le syndrome de retard de phase et la dépression parmi les jeunes : revue systématique et méta-analyse.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Pooled it
- Gut Microbiota and Metabolites: Orchestrating Depression Pathogenesis Through the Microbiota-Gut-Brain Axis's Neural, Immune, and Metabolic Routes.Biomolecules · 2026Review
- Experimental change in temperament: Conversion of the low exploratory phenotype into highly explorative by overexpression of GDNF in the rat striatum.Molecular psychiatry · 2026Article
- ENX-104: a selective and potent DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Geriatric Depression Mimicking Parkinson's Disease: A Case of Levodopa-Responsive Pseudoparkinsonism With a 3-Year Follow-Up.Clinical case reports · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy: Sex Differences and Neurochemical Mechanisms.International journal of molecular sciences · 2026Article
- Motor signs in late life depression relate to altered subcortical synaptic density and gray matter volume: anNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.Brain : a journal of neurology · 2026Review
- Altered Habenula Resting-State Functional Connectivity and Spatial Associations with Neurotransmitter Receptor Distribution of Major Depressive Disorder with and without Anhedonia.Neuropsychiatric disease and treatment · 2026Article
- Deoxycholic acid promotes anxiety- and depression-like behaviors in mice via modulation of the gut microbial metabolite indole-3-propionic acid.Frontiers in immunology · 2026Article
- Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation.Molecular psychiatry · 2026Article
- The Complex Role of Serotonin-Dopamine-Glutamate Receptors in Major Depression.Advances in experimental medicine and biology · 2026Review
- α-synuclein in Parkinson's disease: a central point of convergence with depression.NPJ Parkinson's disease · 2025Review
- Molecular Mechanisms Explaining Neuroanatomical Subtypes in Major Depressive Disorder: Insights From Cortical Morphometric Inverse Divergence.Human brain mapping · 2025Article
- Hesperidin Attenuates Chronic Stress-Induced Depression via 5-HT2A-Linked Modulation of Neurochemical, Oxidative, and Inflammatory Pathways: Experimental and In Silico Evidence.Neurochemical research · 2025Article
- Neuromelanin-Sensitive MRI Contrast and Chronic Depression in Young Women.JAMA network open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is a leading cause of global disability. Several lines of evidence implicate the dopamine system in its pathophysiology. However, the magnitude and consistency of the findings are unknown. We address this by systematically reviewing in vivo imaging evidence for dopamine measures in MDD and meta-analysing these where there are sufficient studies.
methodsStudies investigating the dopaminergic system using positron emission tomography or single photon emission computed tomography in MDD and a control group were included. Demographic, clinical and imaging measures were extracted from each study, and meta-analyses and sensitivity analyses were conducted.
resultsWe identified 43 studies including 662 patients and 801 controls. Meta-analysis of 38 studies showed no difference in mean or mean variability of striatal D
conclusionsThe meta-analysis indicates striatal DAT availability is lower, but D
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.