Evidence map›Paper›PMID 37811363›Full record

ArticleResuscitation plus2023

Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest.

Boya Zhang, Brendan M McCracken, Carmen Colmenero Mahmood, Danielle Leander, Nicholas Greer, James A Cranford, Cindy H Hsu, Mohamad Hakam Tiba, Robert W Neumar, Colin F Greineder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Boya ZhangDepartments of Emergency Medicine, University of Michigan, United States.
Brendan M McCrackenDepartments of Emergency Medicine, University of Michigan, United States.
Carmen Colmenero MahmoodDepartments of Emergency Medicine, University of Michigan, United States.
Danielle LeanderDepartments of Emergency Medicine, University of Michigan, United States.
Nicholas GreerDepartments of Emergency Medicine, University of Michigan, United States.
James A CranfordDepartments of Emergency Medicine, University of Michigan, United States.
Cindy H HsuDepartments of Emergency Medicine, University of Michigan, United States.
Mohamad Hakam TibaDepartments of Emergency Medicine, University of Michigan, United States.
Robert W NeumarDepartments of Emergency Medicine, University of Michigan, United States.
Colin F GreinederDepartments of Emergency Medicine, University of Michigan, United States.
University of Michigan · US

Funding

ICAM-1 targeted thrombomodulin: an experimental therapeutic for the Acute Respiratory Distress SyndromeK08HL130430 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GREINEDER, COLIN FRED · 2016 to 2020
$665k
NHLBI NIH HHS K08 HL130430
6 · The paper itself

Abstract

Aim: To evaluate coagulofibrinolytic abnormalities and the effects of ART-123 (recombinant human thrombomodulin alpha) in a porcine model of cardiac arrest and prolonged cardiopulmonary resuscitation (CA/CPR). Methods: Fifteen pigs ( Results: In saline-treated CA/CPR, but not sham animals, robust and persistent activation of coagulation and fibrinolysis was observed throughout resuscitation. After 50 minutes of CPR, plasma tests and thromboelastography indicated a mix of hypercoagulability and consumptive coagulopathy. ART-123 had a robust anticoagulant effect, reducing both thrombin-antithrombin (TAT) complexes and d-dimer ( Conclusion: A porcine model of prolonged CA/CPR reproduces many of the coagulofibrinolytic abnormalities observed in human cardiac arrest patients. ART-123 demonstrates a combination of anticoagulant and profibrinolytic effects, depending on the timing of its administration relative to cardiac arrest.

Indexed as

Cardiac arrestCoagulationFibrinolysisPorcine modelSoluble thrombomodulin

Identifiers

PMID37811363
PMCPMC10550843
OpenAlexW4387083544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.