Evidence map›Paper›PMID 37810990›Full record

ArticleBioactive materials2024

Zwitterionic polymers-armored amyloid-like protein surface combats thrombosis and biofouling.

Xiaohui Mou, Wan Miao, Wentai Zhang, Wenxuan Wang, Qing Ma, Zeyu Du, Xin Li, Nan Huang, Zhilu Yang

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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  5. A hierarchical MgFBioactive materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiaohui MouSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Wan MiaoSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Wentai ZhangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523000, China.
Wenxuan WangSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Qing MaSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Zeyu DuSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Xin LiDepartment of Cardiology, Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Chengdu, Sichuan 610072, China.
Nan HuangSchool of Materials Science and Engineering, Key Lab of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu, 610031, China.
Zhilu YangDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523000, China.
Southwest Jiaotong University · CNSouthern Medical University · CNChengdu Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins, cells and bacteria adhering to the surface of medical devices can lead to thrombosis and infection, resulting in significant clinical mortality. Here, we report a zwitterionic polymers-armored amyloid-like protein surface engineering strategy we called as "armored-tank" strategy for dual functionalization of medical devices. The "armored-tank" strategy is realized by decoration of partially conformational transformed LZM (PCTL) assembly through oxidant-mediated process, followed by armoring with super-hydrophilic poly-2-methacryloyloxyethyl phosphorylcholine (pMPC). The outer armor of the "armored-tank" shows potent and durable zone defense against fibrinogen, platelet and bacteria adhesion, leading to long-term antithrombogenic properties over 14 days

Indexed as

Amyloid-like proteinAntifoulingAntithrombosisSuper-HydrophilicityZwitterionic polymers

Identifiers

PMID37810990
PMCPMC10556425
OpenAlexW4387083599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.