Evidence map›Paper›PMID 37810243›Full record

ArticleiScience2023

Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus.

Elle C Roberson, Ngan Kim Tran, Anushka N Godambe, Harrison Mark, Michelle Nguimtsop, Trinity Rust, Elizabeth Ung, LeCaine J Barker, Rebecca D Fitch, John B Wallingford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mechanism of action of IHH in ameliorating thin endometrium.The Journal of reproduction and development · 2025
    Article
  5. Decoding Müllerian Duct Epithelial Regionalization.Molecular reproduction and development · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elle C RobersonDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.
Ngan Kim TranDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Anushka N GodambeDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Harrison MarkDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Michelle NguimtsopDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Trinity RustDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Elizabeth UngDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.
LeCaine J BarkerDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.
Rebecca D FitchDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
John B WallingfordDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Funding

Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
Development and function in mucociliary epitheliaR01HL117164 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2013 to 2026
$4.7M
CRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2M
Epithelial Regeneration in the Adult OviductF32HD095618 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI ROBERSON, ELLE · 2018 to 2022
$233k
NHLBI NIH HHS R01 HL117164NICHD NIH HHS F32 HD095618NICHD NIH HHS R01 HD085901NICHD NIH HHS R24 HD102061
6 · The paper itself

Abstract

Decades of work demonstrate that the mammalian estrous cycle is controlled by cycling steroid hormones. However, the signaling mechanisms that act downstream, linking hormonal action to the physical remodeling of the cycling uterus, remain unclear. To address this issue, we analyzed gene expression at all stages of the mouse estrous cycle. Strikingly, we found that several genetic programs well-known to control tissue morphogenesis in developing embryos displayed cyclical patterns of expression. We find that most of the genetic architectures of Hedgehog signaling (ligands, receptors, effectors, and transcription factors) are transcribed cyclically in the uterus, and that conditional disruption of the Hedgehog receptor

Indexed as

Biological sciencesCell biologyDevelopmental biology

Identifiers

PMID37810243
PMCPMC10551904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.