Analysis of HepG2 cell response to a wide concentration range of mitomycin C using a multichannel quartz crystal microbalance system with a microscope.

Hiroshi Muramatsu, Masahiro Naka, Sae Ito, Maki Kawamura

Abstract read

In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hiroshi MuramatsuSchool of Bioscience and Biotechnology, Tokyo University of Technology, 1401-1 Katakura, Hachioji, Tokyo 192-0982, Japan.

Masahiro NakaSchool of Bioscience and Biotechnology, Tokyo University of Technology, 1401-1 Katakura, Hachioji, Tokyo 192-0982, Japan.

Sae ItoSchool of Bioscience and Biotechnology, Tokyo University of Technology, 1401-1 Katakura, Hachioji, Tokyo 192-0982, Japan.

Maki KawamuraSchool of Bioscience and Biotechnology, Tokyo University of Technology, 1401-1 Katakura, Hachioji, Tokyo 192-0982, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphological response of HepG2 cells to mitomycin C was analyzed using a multichannel quartz crystal microbalance system equipped with a home-built movable microscope that enables the simultaneous acquisition of cell images and measurements of eight-channel quartz crystal microbalance. After 24 h of cell seeding, mitomycin C was injected into the culture medium. During the attachment process, the resonant frequency decreased, and the curves fitted well with the first-order lag response. Analysis of the response to mitomycin C revealed that the resonant frequency response curves varied with mitomycin C concentration. When the mitomycin C concentration was <10 μmol L

Indexed as

Cumulative log-normal distributionFirst-order lag responseHepG2 cellsMitomycin CModeling curvesQuartz crystal microbalance

Identifiers

PMID37809730

DOI10.1016/j.heliyon.2023.e20047

PMCPMC10559775

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.