ArticleHeliyon2023
Systemic immune-inflammation index combined with quick sequential organ failure assessment score for predicting mortality in sepsis patients.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Systemic immune-inflammation index and the short-term mortality of patients with sepsis: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Association between the systemic immune-inflammation index within 1 h after birth and the risk of neonatal respiratory distress syndrome in preterm infants.BMC pediatrics · 2026Article
- Association between systemic immune-inflammation index and ICU-acquired infection in critically Ill patients without infection: a competing risks analysis from a retrospective cohort.BMC infectious diseases · 2026Article
- Prognostic Value of the Systemic Immune-Inflammation Index (SII) for short-term clinical outcomes in the emergency department: a retrospective cohort study.BMC emergency medicine · 2026Article
- Relationship between systemic immune-inflammation index and risk of mortality among pneumonia patients: a systematic review with meta-analysis.Journal of thoracic disease · 2026Article
- Development and validation of a sepsis-specific systemic inflammation classification system for mortality prediction.Frontiers in medicine · 2026Article
- Telodendrimer nanotrap for selective cytokine removal from sepsis patient plasma.Frontiers in immunology · 2026Article
- Prognostic value of NPR and CLR-based nomogram modeling in elderly patients with Acinetobacter baumannii bloodstream infection.BMC geriatrics · 2025Article
- The Role of qSOFA, Derived Neutrophil-to-Lymphocyte Ratio, MEWS, and PIRO Scores in Predicting the Severity of Odontogenic Infections in Young and Adult Patients.Biomedicines · 2025Article
- Elevated systemic immune-inflammation index is associated with stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2025Article
- Trajectory of the systemic immune-inflammation index and in-hospital mortality in patients with sepsis.Frontiers in cellular and infection microbiology · 2025Article
- Association between hematological inflammatory markers and latent TB infection: insights from NHANES 2011-2012 and transcriptomic data.Frontiers in cellular and infection microbiology · 2025Article
- Systemic immune-inflammatory complex index as a novel predictor of sepsis prognosis: a retrospective cohort study using MIMIC-IV.Frontiers in medicine · 2025Article
- Article
- Prognostic value of the systemic immune-inflammation index in critically ill elderly patients with hip fracture: evidence from MIMIC (2008-2019).Frontiers in medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the prognostic ability of systemic immune-inflammation index (SII) combine with quick Sequential Organ Failure Assessment (qSOFA) criteria in predicting the 28-day mortality of sepsis. Methods: A retrospective cohort study was conducted, with the population comprised in whom sepsis was confirmed. Clinical and laboratory data recorded were analyzed. The score of Sequential Organ Failure Assessment (SOFA), SII, qSOFA were calculated. Multivariable regression, receiver operating characteristic (ROC) analysis and Kaplan-Meier method were used to identify and compared the predictors of prognosis among SOFA, qSOFA, and the combination of SII with qSOFA. Results: A total of 349 patients admitted from December 2020 and December 2022 were included in the cohort. 95 (27.2%) of whom had died by day 28. The SII, SOFA, and qSOFA scores were significant higher in the non-survivors than that of survivors (P < 0.05), and identified as independent predictors of sepsis mortality. The addition of SII to qSOFA shown an area under receiver operator characteristic (AUROC) of 0.840 (95% CI: 0.787-0.884), manifested an effective ability in predicting poor outcome than other scoring systems. The optimum cutoff for SII (>1.7668) and qSOFA (>1) represented a high risk level in 28-day mortality of sepsis, were performed and identified in Kaplan-Meier survival curves (log-rank test, HR: 6.942, 95% CI: 3.976-12.121; P < 0.0001). Conclusion: The SII in addition to qSOFA provided an effective prognostic tool for predicting mortality in sepsis.
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