Evidence map›Paper›PMID 37809453›Full record

ArticleHeliyon2023

Integrating network pharmacology and experimental verification strategies to reveal the active ingredients and molecular mechanism of Tenghuang Jiangu Capsule against osteoporosis.

Miao Li, Hongyu Tang, Yuanhao Hu, Songtao Li, Pan Kang, Baihao Chen, Shaocong Li, Meng Zhang, Haibin Wang, Shaochuan Huo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Miao LiGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Hongyu TangGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Yuanhao HuGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Songtao LiGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Pan KangGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Baihao ChenGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Shaocong LiGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Meng ZhangDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Haibin WangGuangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Shaochuan HuoShenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, No.6001, North Ring Road, Futian District, Shenzhen City, Guangdong Province, 518048, China.
Guangzhou University of Chinese Medicine · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenghuang Jiangu Capsule (THJGC) is a Chinese herbal formula used for the treatment of osteoporosis and osteoarthritis in China, but its mechanism for treating osteoporosis is not clear. The aim of this study was to investigate the therapeutic effect of THJGC on osteoporosis and its intrinsic mechanism through network pharmacology and experimental validation. Drugs and potential targets were obtained from several reliable databases through network pharmacology, and these targets were integrated and analyzed using bioinformatics and molecular docking strategies. Quercetin, lignans and kaempferol were identified as key components, and the key targets included Akt1, MAPKs, and CASP3. Subsequently, UPLC-MS/MS analysis confirmed the presence of components in THJGC for the treatment of osteoporosis. In addition, using ex vivo and in vivo models, it was confirmed that THJGC inhibited H

Indexed as

Bone formationExperimental validationNetwork pharmacologyOsteoporosisTeng Huang Jian Gu capsule (THJGC)

Identifiers

PMID37809453
PMCPMC10559171
OpenAlexW4386413282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.