Evidence map›Paper›PMID 37809344›Full record

ArticleFrontiers in medicine2023

Herpetic anterior uveitis following COVID-19 vaccines: a case series.

Muriel Ott, Thanoosha Nagamany, Souska Zandi, Francesco Pichi, Aniruddha Agarwal, Ester Carreño, Vishali Gupta, Dilraj S Grewal, Emmett T Cunningham, Marion R Munk

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Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muriel OttDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Thanoosha NagamanyDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Souska ZandiDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Francesco PichiCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Aniruddha AgarwalCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Ester CarreñoDepartment of Ophthalmology, University Hospital Fundación Jimenez Diaz, Madrid, Spain.
Vishali GuptaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dilraj S GrewalDepartment of Ophthalmology, Duke University, Durham, NC, United States.
Emmett T CunninghamDepartment of Ophthalmology, California Pacific Medical Center, San Francisco, CA, United States.
Marion R MunkDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report a case series of herpetic uveitis following COVID-19 vaccinations. Methods: Demographic, clinical and treatment-related data of herpetic anterior uveitis cases was collected at five tertiary eye hospitals between January 2021 and June 2022. A retrospective database review at one of the centers comparing the number of cases of herpetic eye disease before and after the introduction of COVID-19 vaccination was performed as well. Results: Twenty-four patients (9 female, 15 male) with a mean age of 54 years (range 28-83 years) were diagnosed with herpetic uveitis, reporting an onset of symptoms 3-42 days after the first, second or third dose of COVID-19 vaccination. Median time between vaccination and onset of herpetic eye disease was 10 days (mean 12.7 ± 10.15 days) days. The administered vaccines were BNT162b2, mRNA-1273, BBIBP-CorV and Ad26.COV2.S. The cases included 11 HSV, 10 VZV and 1 CMV anterior uveitis, 2 were not further specified. There was an equal number of first episodes ( Conclusion: This report includes 24 cases of herpetic anterior uveitis in a temporal relationship to various COVID-19 vaccines. This study supports the potential risk of herpetic eye disease following COVID-19 vaccines, but proof of a direct, causal relationship is missing.

Indexed as

COVID-19 vaccinesherpes zoster ophthalmicusherpetic eye diseasekeratitismRNA vaccinationocular herpes simplexSARS-CoV-2 vaccinationuveitis

Identifiers

PMID37809344
PMCPMC10556457

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