ArticleFrontiers in medicine2023
Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis.
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Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 8 citations in OpenAlex.
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- Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables.Scientific reports · 2024Article
- Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects.Frontiers in cellular and infection microbiology · 2024Review
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Authors and funding
95 authors at 5 institutions in 1 country.
Emilia Roy-VallejoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Sara Fernández De Córdoba-OñateRheumathology Department, Hospital Universitario La Princesa, Madrid, Spain.
Pablo Delgado-WickeMolecular Biology Unit, Hospital Universitario La Princesa, Madrid, Spain.
Ana Triguero-MartínezInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Nuria MontesInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Rosa Carracedo-RodríguezMolecular Biology Unit, Hospital Universitario La Princesa, Madrid, Spain.
Nelly Zurita-CruzMicrobiology Department, Hospital Universitario La Princesa, Madrid, Spain.
Ana Marcos-JiménezInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Amalia LamanaCell Biology Department, Facultad de Biología, Universidad Complutense, Madrid, Spain.
José María Galván-RománInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Gonzalo Villapalos GarcíaInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Pablo ZubiaurInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Marianela CiudadInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Laura RabesInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Marta SanzInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Carlos RodríguezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Almudena VillaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Jesús Álvarez RodríguezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Celeste MarcosPneumology Department, Hospital Universitario La Princesa, Madrid, Spain.
Julia HernandoAnesthesiology Department, Hospital Universitario La Princesa, Madrid, Spain.
Paula Díaz-FernándezInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Francisco AbadInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Ignacio de Los SantosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Diego A Rodríguez SerranoIntensive Care Unit, Hospital Universitario La Princesa, Madrid, Spain.
Rosario García-VicuñaInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Carmen Suárez FernándezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Rosa P GomarizCell Biology Department, Facultad de Biología, Universidad Complutense, Madrid, Spain.
Cecilia Muñoz-CallejaInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Elena Fernández-RuizInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Isidoro González-ÁlvaroInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Laura CardeñosoInstituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
PREDINMUN-COVID Group
Ana BarriosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Jesús SanzInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pedro CasadoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Ángela GutiérrezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Azucena BautistaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pilar HernándezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Nuria Ruiz GiménezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Berta MoyanoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Paloma GilInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
María Jesús DelgadoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pedro ParraInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Beatriz SánchezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Carmen SáezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Marta Fernández RicoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Cristina Arévalo RománInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Santos CastañedaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Irene LlorenteInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Eva G TomeroInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Noelia García CastañedaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Miren UriarteInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Leticia Fontán García-RodrigoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Diego Domingo GarcíaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Teresa Alarcón CaveroInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
María Auxiliadora Semiglia ChongInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Ainhoa Gutiérrez CobosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Francisco Sánchez-MadridInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Enrique Martín GayoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Ildefonso Sánchez-CerrilloInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pedro Martínez-FletaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Celia López-SanzInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Ligia GabrieInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Luciana Del Campo GuerolaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Reyes TejedorInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Julio AncocheaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Elena García CastilloInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Elena ÁvalosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Ana Sánchez-AzofraInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Tamara AlonsoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Carolina CisnerosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Claudia ValenzuelaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Francisco Javier García PérezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Rosa María GirónInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Javier AspaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Celeste MarcosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
M Del Perpetuo Socorro ChurrucaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Enrique ZamoraInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Adrián MartínezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Mar Barrio MayoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Rosalina Henares EspiInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Rosa MéndezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
David ArribasInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Marta Chicot LlanoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Begoña GonzálezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Begoña QuiciosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pablo PatiñoInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Marina TriguerosInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Cristina Dominguez PeñaInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
David Jiménez JiménezInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Pablo VillamayorInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Alfonso CanabalInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Rafael de la CámaraInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Javier OrtizInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Isabel IturrateInternal Medicine Department, Hospital Universitario La Princesa, Madrid, Spain.
Hospital Universitario de La Princesa · ESUniversidad Autónoma de Madrid · ESUniversidad Complutense de Madrid · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESInstituto de Salud Carlos III · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: SARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity. Materials and methods: Retrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed. Results: The mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 ( Conclusion: Genetic variants in
Indexed as
COVID-19genetic variantsSARS-CoV-2single nucleotide polymorphism (SNPs)viremia
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