Evidence map›Paper›PMID 37809274›Full record

ArticleCureus2023

Retrospective Analysis of the Areas Responsible for Light Flash and Odor During Proton Beam Therapy and Photon Therapy.

Yoshiko Oshiro, Masashi Mizumoto, Toshio Miyamoto, Taisuke Sumiya, Den Fujioka, Haruka Shirataki, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Yoshiko OshiroDepartment of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, JPN.
Masashi MizumotoDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Toshio MiyamotoDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Taisuke SumiyaDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Den FujiokaDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Haruka ShiratakiDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Masatoshi NakamuraDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Toshiki IshidaDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Takashi IizumiDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, JPN.
Takashi SaitoDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Haruko NumajiriDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, JPN.
Hirokazu MakishimaDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JPN.
Kei NakaiDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Kazushi MaruoDepartment of Biostatistics, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Takeji SakaeDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, JPN.
Hideyuki SakuraiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JPN.
University of Tsukuba Hospital · JPUniversity of Tsukuba · JPIbaraki Prefectural Central Hospital · JPTsukuba Medical Center Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Abnormal sensations were frequently experienced by patients who received irradiation of the brain or head and neck region. We have previously suggested correlations with irradiation of the nasal cavity and retina. Purpose We performed a retrospective dose-volume histogram analysis focused on the brain and head and neck tumor to examine the relationship between these abnormal sensations and the details of irradiation. Methods Multivariate logistic regression models were applied for the presence or absence of light flash and odor. Gender, age, radiotherapy method (proton beam therapy vs. photon radiotherapy), dose of retina, optic nerve, chiasmatic gland, pituitary, nasal cavity, oral cavity, frontal lobe, parietal lobe, occipital lobe, temporal lobe, amygdala, and hippocampus were set as candidates of explanatory variables. Results Light flash and odor during radiotherapy have been suggested to be associated with younger age and retina and nasal cavity irradiation. Multivariate analyses including dose-volume histograms indicated that light flash was related to age, chiasmatic gland irradiation, and pituitary dose, and odor was related to age and nasal cavity irradiation. Conclusion Our results indicate that light flash during radiotherapy is caused by irradiation of the visual pathway and that odor is caused by irradiation of the nasal cavity or olfactory bulb.

Indexed as

brainlight flashodorprotonradiotherapy

Identifiers

PMID37809274
PMCPMC10558275
OpenAlexW4386471585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.