Evidence map›Paper›PMID 37808859›Full record

ArticlebioRxiv : the preprint server for biology2023

Enhancers associated with unstable RNAs are rare in plants.

Bayley R Mcdonald, Colette Picard, Ian M Brabb, Marina I Savenkova, Robert J Schmitz, Steven E Jacobsen, Sascha H Duttke

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Bayley R McdonaldSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Colette PicardDepartment of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.
Ian M BrabbSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Marina I SavenkovaSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Robert J SchmitzDepartment of Genetics, University of Georgia, Athens, GA, USA.
Steven E JacobsenDepartment of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.
Sascha H DuttkeSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.

Funding

Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionR00GM135515 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTKE, SASCHA H. · 2022 to 2024
$747k
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIGMS NIH HHS R00 GM135515NIH HHS S10 OD026929
6 · The paper itself

Abstract

Unstable transcripts have emerged as markers of active enhancers in vertebrates and shown to be involved in many cellular processes and medical disorders. However, their prevalence and role in plants is largely unexplored. Here, we comprehensively captured all actively initiating ("nascent") transcripts across diverse crops and other plants using capped small (cs)RNA-seq. We discovered that unstable transcripts are rare, unlike in vertebrates, and often originate from promoters. Additionally, many "distal" elements in plants initiate tissue-specific stable transcripts and are likely

Identifiers

PMID37808859
PMCPMC10557634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.