Evidence map›Paper›PMID 37808853›Full record

ArticlebioRxiv : the preprint server for biology2023

Tissue-specific knockout in

Xinchen Chen, Sarah Perry, Bei Wang, Shuran Wang, Jiayi Hu, Elizabeth Loxterkamp, Dion Dickman, Chun Han

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xinchen ChenWeill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Sarah PerryDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.
Bei WangWeill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Shuran WangWeill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Jiayi HuWeill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Elizabeth LoxterkampDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.
Chun HanWeill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Cornell University · USUniversity of Southern California · US

Funding

Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
MAGIC tools for genome-wide mosaic analysis with existing Drosophila resources (Equipment Supplement 2023)R24OD031953 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2022 to 2025
$3.1M
Mechanisms of the recognition of degenerating dendritesR01NS099125 · NINDS · CORNELL UNIVERSITY · PI HAN, CHUN · 2016 to 2020
$2.1M
Generating functional diversity from molecular homogeneity at glutamatergic synapsesR01NS126654 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DION KAI DICKMAN · 2023 to 2026
$1.8M
A light-inducible protein trapping system for studying cellular dynamics in DrosophilaR21OD023824 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2017 to 2018
$414k
NIH HHS R21 OD023824NIH HHS R24 OD031953NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS099125NINDS NIH HHS R01 NS126654
6 · The paper itself

Abstract

Tissue-specific gene knockout by CRISPR/Cas9 is a powerful approach for characterizing gene functions in animal development. However, this approach has been successfully applied in only a small number of

Indexed as

CRISPR/Cas9CRISPR-TRiMDrosophilaESCRTextracellular vesiclesneuromuscular junctionSNAREtissue specific

Identifiers

PMID37808853
PMCPMC10557614
OpenAlexW4387006544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.