Evidence map›Paper›PMID 37808838›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Usage of Mineralocorticoids and Isotonic Crystalloids in Subarachnoid Hemorrhage Patients in the United States.

Akshitkumar M Mistry, Janki Naidugari, Jocelyn Craven, Logan Williams, Jonathan Beall, Pooja Khatri, Joseph P Broderick, Todd W Rice, Hooman Kamel, William Mack

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Akshitkumar M MistryDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Janki NaidugariSchool of Medicine, University of Louisville, Louisville, KY, USA.
Jocelyn CravenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Logan WilliamsDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Jonathan BeallDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Pooja KhatriDepartments of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH, USA.
Joseph P BroderickDepartments of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH, USA.
Todd W RiceDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hooman KamelClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
William MackDepartment of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Medical University of South Carolina · USUniversity of Cincinnati Medical Center · USUniversity of Louisville · USCornell University · USUniversity of Southern California · USVanderbilt University Medical Center · US

Funding

NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
Workshop to Identify Collaborative Project(s) for the NIH StrokeNet and the Japan NEtwork for Clinical Stroke Trials (NECST)U01NS087748 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Catherine R. Dillon, Jordan J. Elm · 2014 to 2026
$14.1M
NINDS NIH HHS U01 NS086872NINDS NIH HHS U01 NS087748
6 · The paper itself

Abstract

Background: The usage rates of mineralocorticoids (fludrocortisone) to treat hyponatremia and isotonic crystalloids (saline and balanced crystalloids) to maintain intravascular volume in patients with aneurysmal subarachnoid hemorrhage (aSAH) patients across the United States are unknown. Methods: We surveyed National Institute of Neurologic Disorders and Stroke (NINDS) StrokeNet sites, which are mostly large, tertiary, academic centers, and analyzed subarachnoid hemorrhage encounters in the Premier Healthcare Database that is representative of all types of hospitals and captures about 20% of all acute inpatient care in the United States. Results: Although mineralocorticoids are used by 70% of the NINDS StrokeNet sites in aSAH patients, it is used in less than 25% of the aSAH encounters in the Premier Database. Although saline is ubiquitously used, balanced crystalloids are increasingly used for fluid therapy in aSAH patients. Its use in the NINDS StrokeNet sites and the Premier Healthcare Database is 41% and 45%, respectively. Conclusions: The use of mineralocorticoids remains low, and balanced crystalloids are increasingly used as fluid therapy in aSAH patients. The effectiveness of mineralocorticoids and balanced crystalloids in improving outcomes for aSAH patients must be rigorously tested in randomized clinical trials.

Indexed as

Critical CareFludrocortisoneFluidsMineralocorticoidSubarachnoid hemorrhage

Identifiers

PMID37808838
PMCPMC10557832
OpenAlexW4387164095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.