Evidence map›Paper›PMID 37808834›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularis.

Ahmad Rajeh, Hannah L Cornman, Anuj Gupta, Mindy D Szeto, Anusha Kambala, Olusola Oladipo, Varsha Parthasarathy, Junwen Deng, Sarah Wheelan, Thomas Pritchard and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Ahmad RajehDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hannah L CornmanDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anuj GuptaThe Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Mindy D SzetoDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anusha KambalaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Olusola OladipoDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Varsha ParthasarathyDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Junwen DengDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah WheelanPresent affiliation: National Human Genome Research Institute, National Institute of Health, Bethesda, MD, USA.
Thomas PritchardDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Madan M KwatraDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
Yevgeniy R SemenovDepartment of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
Alexander GusevDivision of Genetics, Brigham & Women's Hospital, Boston, MA, USA.
Srinivasan YegnasubramanianThe Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Shawn G KwatraDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBrigham and Women's Hospital · USDuke University · USHarvard University · USNational Human Genome Research Institute · USSidney Kimmel Comprehensive Cancer Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Racial Differences in Biomarkers and Therapeutic Targets for Chronic ItchK23AR077073 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI KWATRA, SHAWN GAURAV · 2021 to 2025
$873k
NCI NIH HHS P30 CA006973NIAMS NIH HHS K23 AR077073
6 · The paper itself

Abstract

Prurigo nodularis (PN) is a chronic inflammatory skin disease that disproportionately affects African Americans and is characterized by pruritic skin nodules of unknown etiology. Little is known about genetic alterations in PN pathogenesis, especially relating to somatic events which are often implicated in inflammatory conditions. We thus performed whole-exome sequencing on 54 lesional and nonlesional skin biopsies from 17 PN patients and 10 atopic dermatitis (AD) patients for comparison. Somatic mutational analysis revealed that PN lesional skin harbors pervasive somatic mutations in fibrotic, neurotropic, and cancer-associated genes. Nonsynonymous mutations were most frequent in

Identifiers

PMID37808834
PMCPMC10557842
OpenAlexW4387036631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.