Evidence map›Paper›PMID 37808818›Full record

ArticlebioRxiv : the preprint server for biology2024

OpenCell: A Low-cost, Open-Source, 3-in-1 device for DNA Extraction.

Aryan Gupta, Justin Yu, Elio J Challita, Janet Standeven, M Saad Bhamla

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aryan GuptaSchool of Electrical & Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA.ORCID 0009-0002-7347-4533
Justin YuSchool of Biological Sciences, Georgia Institute of Technology, 310 Ferst Dr NW, Atlanta, GA 30332, USA.
Elio J ChallitaSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA, 30332, USA.
Janet StandevenSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA, 30332, USA.
M Saad BhamlaSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA, 30332, USA.ORCID 0000-0002-9788-9920
Georgia Institute of Technology · US

Funding

Biophysical mechanism and synthetic engineering of optically-controlled Ca2+-powered supramolecular enginesR35GM142588 · NIGMS · UNIVERSITY OF COLORADO · PI SAAD BHAMLA · 2021 to 2026
$4.4M
Frugal Science Academy: Training K-12 innovators and democratizing synthetic biology toolsR25GM142044 · NIGMS · UNIVERSITY OF COLORADO · PI SAAD BHAMLA · 2022 to 2026
$1.3M
NIGMS NIH HHS R25 GM142044NIGMS NIH HHS R35 GM142588
6 · The paper itself

Abstract

High-cost DNA extraction procedures pose significant challenges for budget-constrained laboratories. To address this, we introduce OpenCell, an economical, open-source, 3-in-1 laboratory device that combines the functionalities of a bead homogenizer, a microcentrifuge, and a vortex mixer. OpenCell utilizes modular attachments that magnetically connect to a central rotating brushless motor. This motor couples to an epicyclic gearing mechanism, enabling efficient bead homogenization, vortex mixing, and centrifugation within one compact unit. OpenCell's design incorporates multiple redundant safety features, ensuring both the device's and operator's safety. Additional features such as RPM measurement, programmable timers, battery operation, and optional speed control make OpenCell a reliable and reproducible laboratory instrument. In our study, OpenCell successfully isolated DNA from

Identifiers

PMID37808818
PMCPMC10557587
OpenAlexW4387018376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.