Evidence map›Paper›PMID 37808788›Full record

ArticlebioRxiv : the preprint server for biology2024

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts.

Yongfeng Luo, Ke Cao, Joanne Chiu, Hui Chen, Hong-Jun Wang, Matthew E Thornton, Brendan H Grubbs, Martin Kolb, Michael S Parmacek, Yuji Mishina and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yongfeng LuoDepartment of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027.
Ke CaoDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Joanne ChiuDepartment of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027.
Hui ChenDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Hong-Jun WangDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Matthew E ThorntonDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Brendan H GrubbsDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Martin KolbDepartment of Medicine, McMaster University, Hamilton, ON, Canada L8N 4A6.
Michael S ParmacekDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yuji MishinaDepartment of Biologic and Material Sciences, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109.
Wei ShiDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0001-6499-2473
University of Cincinnati Medical Center · USUniversity of Southern California · USMcMaster University · CAUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

Molecular mechanisms of pulmonary disease in Birt-Hogg-Dube syndromeR01HL141352 · NHLBI · UNIVERSITY OF CINCINNATI · PI SHI, WEI · 2018 to 2021
$2.6M
Lung Development and DiseasesR01HL151699 · NHLBI · UNIVERSITY OF CINCINNATI · PI SHI, WEI · 2022 to 2025
$2.0M
NHLBI NIH HHS R01 HL141352NHLBI NIH HHS R01 HL151699
6 · The paper itself

Abstract

Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which developmental defects in lung mesenchymal cells contribute to abnormal airway epithelial cell growth and subsequent cystic lesions has not been thoroughly examined. In the present study, we dissected the roles of BMP receptor 1a (Bmpr1a)-mediated BMP signaling in lung mesenchyme during prenatal lung development and discovered that abrogation of mesenchymal

Indexed as

Airway smooth muscle cellsBmpr1aBMP signalingLung branching morphogenesisLung developmentLung mesenchymal cellsPulmonary cysts

Identifiers

PMID37808788
PMCPMC10557633
OpenAlexW4387081281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.