Evidence map›Paper›PMID 37808771›Full record

ArticlebioRxiv : the preprint server for biology2023

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling: IAFs disrupt colon epithelium via PGE2-EP4.

Yi Dong, Blake A Johnson, Linhao Ruan, Maged Zeineldin, Albert Z Liu, Sumana Raychaudhuri, Ian Chiu, Jin Zhu, Barbara Smith, Nan Zhao and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Yi DongDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Blake A JohnsonDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Linhao RuanDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Maged ZeineldinDepartment of Pathology, Division of GI/Liver Pathology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Albert Z LiuDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Sumana RaychaudhuriDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Ian ChiuDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Jin ZhuMechanobiology Institute and Department of Biological Sciences, National University of Singapore; Singapore.
Barbara SmithMicroscope Facility, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Nan ZhaoInstitute for Nanobiotechnology, Johns Hopkins University; Baltimore, Maryland, 21218, U.S.A.
Peter SearsonInstitute for Nanobiotechnology, Johns Hopkins University; Baltimore, Maryland, 21218, U.S.A.
Shigeki WatanabeDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Mark DonowitzDepartment of Medicine, Division of Gastroenterology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Tatianna C LarmanDepartment of Pathology, Division of GI/Liver Pathology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Rong LiDepartment of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Johns Hopkins University · USNational University of Singapore · SG

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory diseases such as inflammatory bowel disease (IBD), but their direct impact on epithelial function and architecture is unknown. In this study, we developed an

Identifiers

PMID37808771
PMCPMC10557697
OpenAlexW4387172372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.