Evidence map›Paper›PMID 37808768›Full record

ArticlebioRxiv : the preprint server for biology2023

Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of

Maider Astorkia, Yang Liu, Erika M Pedrosa, Herbert M Lachman, Deyou Zheng

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maider AstorkiaDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Yang LiuDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Erika M PedrosaDepartment of Psychiatry and Behavioral Science, Albert Einstein College of Medicine, Bronx, NY, USA.
Herbert M LachmanDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Deyou ZhengDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Albert Einstein College of Medicine · US

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Support for the Rose F. Kennedy IDDRCU54HD090260 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WALKLEY, STEVEN UPSHAW · 2016 to 2020
$6.0M
NICHD NIH HHS P50 HD105352NICHD NIH HHS U54 HD090260
6 · The paper itself

Abstract

About 100 genes have been associated with significantly increased risks of autism spectrum disorders (ASD) with an estimate of ~1000 genes that may be involved. The new challenge now is to investigate the molecular and cellular functions of these genes during neural and brain development, and then even more challenging, to link the altered molecular and cellular phenotypes to the ASD clinical manifestations. In this study, we use single cell RNA-seq analysis to study one of the top risk gene,

Indexed as

ASDAutismcell-cell communicationcerebral organoidCHD8scRNA-seq

Identifiers

PMID37808768
PMCPMC10557718
OpenAlexW4387118555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.