Evidence map›Paper›PMID 37808758›Full record

ArticlebioRxiv : the preprint server for biology2023

Microbially-catalyzed conjugation of GABA and tyramine to bile acids.

Michael W Mullowney, Aretha Fiebig, Matthew K Schnizlein, Mary McMillin, Amber R Rose, Jason Koval, David Rubin, Sushila Dalal, Mitchell L Sogin, Eugene B Chang and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Michael W MullowneyDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Aretha FiebigDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-0612-5029
Matthew K SchnizleinDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-0797-8357
Mary McMillinDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Amber R RoseDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Jason KovalDepartment of Medicine, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
David RubinDepartment of Medicine, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Sushila DalalDepartment of Medicine, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Mitchell L SoginMarine Biological Laboratory, Woods Hole, MA USA.
Eugene B ChangDepartment of Medicine, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Ashley M SidebottomDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL, 60637, USA.
Sean CrossonDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-1727-322X
University of Chicago · USMichigan State University · USMarine Biological Laboratory · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Host and microbial basis of human ulcerative colitis and pouchitis: Identification, role, mechanisms, and resource development of host susceptibility and pathobiont factorsRC2DK122394 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2019 to 2023
$10.2M
Molecular mechanisms controlling stress responses and cell adhesion in bacteriaR35GM131762 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2019 to 2026
$3.2M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072NIDDK NIH HHS RC2 DK122394NIGMS NIH HHS R35 GM131762
6 · The paper itself

Abstract

Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient absorption, regulate host metabolic processes, and influence physiology of the gut microbiota. Both the host and its microbiome contribute to enzymatic modifications that shape the chemical diversity of BAs in the gut. Several bacterial species have been reported to conjugate standard amino acids to BAs, but it was not known if bacteria conjugate BAs to other amine classes. Here, we show that

Identifiers

PMID37808758
PMCPMC10557584
OpenAlexW4387048927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.