Evidence map›Paper›PMID 37808720›Full record

ArticlebioRxiv : the preprint server for biology2023

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4.

Thuy P Dao, Anitha Rajendran, Sarasi K K Galagedera, William Haws, Carlos A Castañeda

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thuy P DaoDepartments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Anitha RajendranDepartments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Sarasi K K GalagederaDepartments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
William HawsDepartments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Carlos A CastañedaDepartments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Syracuse University · US

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
The Role and Mechanisms of UBQLN2-mediated Phase Transitions in the Assembly and Disassembly of Biomolecular CondensatesR01GM136946 · NIGMS · SYRACUSE UNIVERSITY · PI CASTANEDA, CARLOS ANTONIO · 2020 to 2024
$1.5M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
NIGMS NIH HHS P30 GM138395NIGMS NIH HHS R01 GM136946NIH HHS S10 OD018090
6 · The paper itself

Abstract

Highly homologous ubiquitin-binding shuttle proteins UBQLN1, UBQLN2 and UBQLN4 differ in both their specific protein quality control functions and their propensities to localize to stress-induced condensates, cellular aggregates and aggresomes. We previously showed that UBQLN2 phase separates

Indexed as

charge stateepitope tagsN-terminal disordered regionPhase separationproline-rich regionUBQLN1UBQLN2UBQLN4

Identifiers

PMID37808720
PMCPMC10557701
OpenAlexW4387159433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.