Evidence map›Paper›PMID 37808699›Full record

ArticlebioRxiv : the preprint server for biology2023

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation.

Magda Wąhalska, Celeste Riepe, Magdalena J Ślusarz, Małgorzata Graul, Lukasz S Borowski, Wenjie Qiao, Michalina Foltynska, Jan E Carette, Krystyna Bieńkowska-Szewczyk, Roman J Szczesny and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Magda WąhalskaLaboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Celeste RiepeDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Magdalena J ŚlusarzDepartment of Theoretical Chemistry, Faculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.
Małgorzata GraulLaboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Lukasz S BorowskiInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 02-106 Warsaw, Poland.
Wenjie QiaoDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Michalina FoltynskaLaboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Jan E CaretteDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Krystyna Bieńkowska-SzewczykLaboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Roman J SzczesnyInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Ron R KopitoDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Andrea D LipińskaLaboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.
Gdańsk Medical University · PLStanford University · USInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLUniversity of Gdańsk · PLUniversity of Warsaw · PL

Funding

The Ubiquitin Proteasome System in Quality ControlR01GM074874 · NIGMS · STANFORD UNIVERSITY · PI KOPITO, RON R · 2006 to 2022
$8.0M
Protein Aggregation and Inclusion Body FormationR01NS042842 · NINDS · STANFORD UNIVERSITY · PI KOPITO, RON R · 2002 to 2016
$6.1M
Protein Aggregation and Inclusion Body FormationR56NS042842 · NINDS · STANFORD UNIVERSITY · PI KOPITO, RON R · 2007 to 2019
$1.1M
Four Laser, 18 Color Cell Sorter in the SSFFS10RR025518 · NCRR · STANFORD UNIVERSITY · PI HERZENBERG, LEONARD A · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025518NIGMS NIH HHS R01 GM074874NINDS NIH HHS R01 NS042842NINDS NIH HHS R56 NS042842
6 · The paper itself

Abstract

The transporter associated with antigen processing (TAP) is a key player in the MHC class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 (BoHV-1) impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in which binding of the UL49.5 gene product to TAP both inhibits peptide transport and promotes its proteasomal degradation. How UL49.5 promotes TAP degradation is unknown. Here, we use high-content siRNA and genome-wide CRISPR-Cas9 screening to identify CLR2

Identifiers

PMID37808699
PMCPMC10557673
OpenAlexW4387127505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.