Evidence map›Paper›PMID 37808693›Full record

ArticlebioRxiv : the preprint server for biology2023

The impact of phage and phage resistance on microbial community dynamics.

Ellinor O Alseth, Rafael Custodio, Sarah A Sundius, Rachel A Kuske, Sam P Brown, Edze R Westra

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ellinor O AlsethEnvironment and Sustainability Institute, Biosciences, University of Exeter, Penryn, UK.
Rafael CustodioEnvironment and Sustainability Institute, Biosciences, University of Exeter, Penryn, UK.
Sarah A SundiusCenter for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
Rachel A KuskeCenter for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
Sam P BrownCenter for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
Edze R WestraEnvironment and Sustainability Institute, Biosciences, University of Exeter, Penryn, UK.
Georgia Institute of Technology · USUniversity of Exeter · GB

Funding

Building re-usable phage and antibiotic treatments via exploitation of bacteria-phage co-evolutionary dynamicsR21AI156817 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI BROWN, SAMUEL PAUL · 2021 to 2022
$434k
NIAID NIH HHS R21 AI156817
6 · The paper itself

Abstract

Where there are bacteria, there will be bacteriophages. These viruses are known to be important players in shaping the wider microbial community in which they are embedded, with potential implications for human health. On the other hand, bacteria possess a range of distinct immune mechanisms that provide protection against bacteriophages, including the mutation or complete loss of the phage receptor, and CRISPR-Cas adaptive immunity. Yet little is known about how interactions between phages and these different phage resistance mechanisms affect the wider microbial community in which they are embedded. Here, we conducted a 10-day, fully factorial evolution experiment to examine how phage impact the structure and dynamics of an artificial four-species bacterial community that includes either

Identifiers

PMID37808693
PMCPMC10557685
OpenAlexW4387149639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.