Evidence map›Paper›PMID 37808678›Full record

ArticlebioRxiv : the preprint server for biology2023

"Tranq-Dope" Overdose and Mortality: Lethality Induced by Fentanyl and Xylazine.

Mark A Smith, Samantha L Biancorosso, Jacob D Camp, Salome H Hailu, Alexandra N Johansen, Mackenzie H Morris, Hannah N Carlson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mark A SmithDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Samantha L BiancorossoDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Jacob D CampDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Salome H HailuDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Alexandra N JohansenDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Mackenzie H MorrisDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Hannah N CarlsonDepartment of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA.
Davidson College · US

Funding

Social Influences on Drug-Seeking BehaviorR01DA031725 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2012 to 2022
$3.1M
The Influence of Gonadal Hormones on Opioid UseR01DA045364 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2018 to 2022
$1.6M
NIDA NIH HHS R01 DA031725NIDA NIH HHS R01 DA045364
6 · The paper itself

Abstract

The recreational use of fentanyl in combination with xylazine (i.e., "tranq-dope") represents a rapidly emerging public health threat characterized by significant toxicity and mortality. This study quantified the interactions between these drugs on lethality and examined the effectiveness of potential rescue medications to prevent a lethal overdose. Male and female mice were administered acute doses of fentanyl, xylazine, or their combination via intraperitoneal injection, and lethality was determined 30, 60, 90, 120, and 1440 min (24 hr) after administration. Both fentanyl and xylazine produced dose-dependent increases in lethality when administered alone. A nonlethal dose of fentanyl (56 mg/kg) produced an approximately 5-fold decrease in the estimated LD

Indexed as

addictionopioid use disorderpreclinical modelsex differencessubstance usesubstance use disorder

Identifiers

PMID37808678
PMCPMC10557575
OpenAlexW4387037292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.