Evidence map›Paper›PMID 37808657›Full record

ArticlebioRxiv : the preprint server for biology2024

Cell type-specific gene expression dynamics during human brain maturation.

Christina Steyn, Ruvimbo Mishi, Stephanie Fillmore, Matthijs B Verhoog, Jessica More, Ursula K Rohlwink, Roger Melvill, James Butler, Johannes M N Enslin, Muazzam Jacobs and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Christina SteynDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Ruvimbo MishiDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Stephanie FillmoreDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Matthijs B VerhoogDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Jessica MoreDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Ursula K RohlwinkNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Roger MelvillDivision of Neurosurgery, Department of Surgery, University of Cape Town, Cape Town, South Africa.
James ButlerNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Johannes M N EnslinNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Muazzam JacobsNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Tatjana Sauka-SpenglerRadcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Maria GrecoSingle Cell Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sadi QuiñonesDepartment of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.
Chris G DullaDepartment of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.
Joseph V RaimondoDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Anthony FigajiNeuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3357-6490
Dorit HockmanDivision of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2613-6216
University of Cape Town · ZATufts University · USNational Health Laboratory Service · ZAStowers Institute for Medical Research · USUniversity of Oxford · GB

Funding

Utilizing Single Cell Biological Approaches to Understand CNS TBR21TW011225 · FIC · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G, JACOBS, MUAZZAM · 2019 to 2020
$291k
FIC NIH HHS R21 TW011225
6 · The paper itself

Abstract

The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. Most studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using single nucleus (sn)RNA-seq on temporal lobe tissue, including samples of African ancestry, we build a joint paediatric and adult atlas of 75 cell subtypes, which we verify with spatial transcriptomics. We explore the differences between paediatric and adult cell types, revealing the genes and pathways that change during brain maturation. Our results highlight excitatory neuron subtypes, including the

Identifiers

PMID37808657
PMCPMC10557738
OpenAlexW4387221114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.