Evidence map›Paper›PMID 37808655›Full record

ArticlebioRxiv : the preprint server for biology2023

A suite of engineered mice for interrogating psychedelic drug actions.

Yi-Ting Chiu, Ariel Y Deutch, Wei Wang, Gavin P Schmitz, Karen Lu Huang, D Dewran Kocak, Pierre Llorach, Kasey Bowyer, Bei Liu, Noah Sciaky and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 14 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Yi-Ting ChiuDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Ariel Y DeutchDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei WangAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, 10021, USA.
Gavin P SchmitzDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Karen Lu HuangDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
D Dewran KocakDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Pierre LlorachDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Kasey BowyerAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, 10021, USA.
Bei LiuDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Noah SciakyDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Kunjie HuaDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Chongguang ChenCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Sarah E MottDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Jesse NiehausDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Jeffrey F DiBertoDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Justin EnglishDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Jessica J WalshDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Grégory ScherrerDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Melissa A HermanDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
Zhuhao WuAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, 10021, USA.
William C WetselDepartments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Bryan L RothDepartment of Pharmacology, University of North Carolina at Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USCornell University · USDuke University · USTemple University · USVanderbilt University · US

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Mechanistic insights into LSD actions at 5-HT2A serotonin receptorsR37DA045657 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth · 2018 to 2026
$5.8M
Neural mechanisms underlying sustained enhancement of sociabilityR01MH136266 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jessica Jillian Walsh · 2024 to 2026
$2.3M
NICHD NIH HHS P50 HD103573NIDA NIH HHS R37 DA045657NIMH NIH HHS R01 MH136266NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder, migraine, and cluster headaches. LSD and psilocybin exert their psychedelic effects via activation of the 5-hydroxytryptamine 2A receptor (HTR2A). Here we provide a suite of engineered mice useful for clarifying the role of HTR2A and HTR2A-expressing neurons in psychedelic drug actions. We first generated

Identifiers

PMID37808655
PMCPMC10557740
OpenAlexW4387039546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.