Evidence map›Paper›PMID 37808647›Full record

ArticlebioRxiv : the preprint server for biology2023

Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.

Lianne M Reus, Toni Boltz, Marcelo Francia, Merel Bot, Naren Ramesh, Maria Koromina, Yolande A L Pijnenburg, Anouk den Braber, Wiesje M van der Flier, Pieter Jelle Visser and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Lianne M ReusORCID 0000-0001-6936-242X
Toni BoltzORCID 0000-0003-0226-7924
Marcelo FranciaORCID 0000-0001-9388-552X
Merel BotORCID 0000-0003-2261-7119
Naren Ramesh
Maria KorominaORCID 0000-0001-8843-082X
Yolande A L PijnenburgORCID 0000-0003-2464-1905
Anouk den Braber
Wiesje M van der FlierORCID 0000-0001-8766-6224
Pieter Jelle VisserORCID 0000-0001-8008-9727
Sven J van der LeeORCID 0000-0003-1606-8643
Betty M TijmsORCID 0000-0002-2612-1797
Charlotte E TeunissenORCID 0000-0002-4061-0837
Loes Olde LoohuisORCID 0000-0002-3327-7837
Roel A OphoffORCID 0000-0002-8287-6457
University of California, Los Angeles · USAmsterdam Neuroscience · NLIcahn School of Medicine at Mount Sinai · USKarolinska Institutet · SE

Funding

Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9M
Genetics of CSF Metabolites in Alzheimer Disease and other Brain DisordersRF1AG058484 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2018 to 2018
$3.8M
NIA NIH HHS RF1 AG058484NIMH NIH HHS R01 MH115676
6 · The paper itself

Abstract

Genomic studies of molecular traits have provided mechanistic insights into complex disease, though these lag behind for brain-related traits due to the inaccessibility of brain tissue. We leveraged cerebrospinal fluid (CSF) to study neurobiological mechanisms

Identifiers

PMID37808647
PMCPMC10557608
OpenAlexW4387118328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.