Evidence map›Paper›PMID 37808400›Full record

ArticleJBMR plus2023

Substantially Delayed Maturation of Growth Plate Chondrocytes in "Humanized"

Monica Reyes, Damla Firat, Patrick Hanna, Mohd Khan, Michael Bruce, Maria Shvedova, Tatsuya Kobayashi, Ernestina Schipani, Thomas J Gardella, Harald Jüppner

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  4. Jansen's Disease: Bone Abnormalities Beyond Chondrodysplasia.The Journal of clinical endocrinology and metabolism · 2025
    Article
  5. Article
  6. Humanized mice to model rare human diseases.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Monica ReyesEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Damla FiratEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Patrick HannaEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Mohd KhanDepartment of Orthopedic Surgery University of Pennsylvania, Perelman Medical School Philadelphia PA USA.
Michael BruceEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Maria ShvedovaEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Tatsuya KobayashiEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.
Ernestina SchipaniDepartment of Orthopedic Surgery University of Pennsylvania, Perelman Medical School Philadelphia PA USA.
Thomas J GardellaEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.ORCID https://orcid.org/0000-0002-2163-5772
Harald JüppnerEndocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA.ORCID https://orcid.org/0000-0001-7491-0515
Harvard University · USUniversity of Pennsylvania · US

Funding

Tissue Phenotyping CoreP01DK011794 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L · 1986 to 2023
$44.4M
Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI MARY L BOUXSEIN, PAOLA DIVIETI PAJEVIC · 2019 to 2026
$7.4M
PTH/PTHRP RECEPTOR DEFECTS IN PSEUDOHYPOPARATHYROIDISMR01DK046718 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JUEPPNER, HARALD W. · 1993 to 2024
$6.0M
Role of miR-17-92 miRNAs in skeletal development and bone homeostasisR01AR056645 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KOBAYASHI, TATSUYA · 2010 to 2020
$4.1M
PTH Inverse Agonists as Therapy for Jansens DiseaseR01DK113039 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI THOMAS J GARDELLA, HARALD W. JUEPPNER · 2018 to 2026
$3.5M
Skeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5M
NIAMS NIH HHS P30 AR066261NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R01 AR056645NIDDK NIH HHS P01 DK011794NIDDK NIH HHS R01 DK046718NIDDK NIH HHS R01 DK113039
6 · The paper itself

Abstract

Activating parathyroid hormone (PTH)/PTH-related Peptide (PTHrP) receptor (PTH1R) mutations causes Jansen's metaphyseal chondrodysplasia (JMC), a rare disease characterized by growth plate abnormalities, short stature, and PTH-independent hypercalcemia. Previously generated transgenic JMC mouse models, in which the human

Indexed as

ANIMAL MODELSBIOCHEMICAL MARKERS OF BONE TURNOVERBONE MODELING AND REMODELINGCELL/TISSUE SIGNALING – ENDOCRINE PATHWAYSCHONDROCYTE AND CARTILAGE BIOLOGYGENETIC ANIMAL MODELSGROWTH PLATEPTH/Vit D/FGF23

Identifiers

PMID37808400
PMCPMC10556264
OpenAlexW4385838488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.