Evidence map›Paper›PMID 37808055›Full record

ArticleJTCVS open2023

Bioinspired polymeric heart valves: A combined in vitro and in silico approach.

Aeryne Lee, Xinying Liu, Jacopo Emilio Giaretta, Thanh Phuong Hoang, Matthew Crago, Syamak Farajikhah, Luke Mosse, David Frederick Fletcher, Fariba Dehghani, David Scott Winlaw and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aeryne LeeSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Xinying LiuSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Jacopo Emilio GiarettaSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Thanh Phuong HoangSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Matthew CragoSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Syamak FarajikhahSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Luke MosseLeap Australia, Clayton North, Australia.
David Frederick FletcherSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
Fariba DehghaniSchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.
David Scott WinlawSchool of Medicine, The University of Sydney, Camperdown, Australia.
Sina NaficySchool of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polymeric heart valves (PHVs) may address the limitations of mechanical and tissue valves in the treatment of valvular heart disease. In this study, a bioinspired valve was designed, assessed in silico, and validated by an in vitro model to develop a valve with optimum function for pediatric applications. Methods: A bioinspired heart valve was created computationally with leaflet curvature derived from native valve anatomies. A valve diameter of 18 mm was chosen to approach sizes suitable for younger patients. Valves of different thicknesses were fabricated via dip-coating with siloxane-based polyurethane and tested in a pulse duplicator for their hydrodynamic function. The same valves were tested computationally using an arbitrary Lagrangian-Eulerian plus immersed solid approach, in which the fluid-structure interaction between the valves and fluid passing through them was studied and compared with experimental data. Results: Computational analysis showed that valves of 110 to 200 μm thickness had effective orifice areas (EOAs) of 1.20 to 1.30 cm Conclusions: Bioinspired PHVs demonstrated good hydrodynamic performance that exceeded ISO 5840-2 standards. Both methods of analysis showed similar correlations between leaflet thickness and valve systolic function. Further development of this PHV may lead to enhanced durability and thus a more reliable heart valve replacement than contemporary options.

Indexed as

bioinspired valve designcomputational modelingheart valve engineeringhydrodynamic testingpolymeric heart valve

Identifiers

PMID37808055
PMCPMC10556942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.