Evidence map›Paper›PMID 37807827›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

cGAS-STING Pathway Activation and Systemic Anti-Tumor Immunity Induction via Photodynamic Nanoparticles with Potent Toxic Platinum DNA Intercalator Against Uveal Melanoma.

Hui Tao, Jia Tan, Hanchen Zhang, Hong Ren, Ziyi Cai, Hanhan Liu, Bingyu Wen, Jiaqi Du, Gaoyang Li, Shijie Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Potential of Nanoparticle-Based Phototherapies for Future Treatment of Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hui TaoDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Jia TanEye Center of Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China.ORCID 0000-0001-6482-818X
Hanchen ZhangBeijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Hong RenDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Ziyi CaiDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Hanhan LiuDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Bingyu WenDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Jiaqi DuDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Gaoyang LiDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Shijie ChenDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Haihua XiaoBeijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Zhihong DengDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.ORCID 0000-0001-9926-4943
Central South University · CNChinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 82071002National Natural Science Foundation of China 82271057Natural Science Foundation of Hunan Province 2019JJ40465
6 · The paper itself

Abstract

The cGAS-STING pathway, as a vital innate immune signaling pathway, has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, a photodynamic polymer (P1) is designed to electrostatically couple with 56MESS-a cationic platinum (II) agent-to form NP

Indexed as

Intercalating AgentsNanoparticlesAnimalsMelanomaMiceNucleotidyltransferasesPlatinumReactive Oxygen SpeciesUveal MelanomaUveal NeoplasmsIntercalating AgentsNucleotidyltransferasesPlatinumReactive Oxygen Species56MESScGAS-STINGimmunotherapynanoparticlesuveal melanoma

Identifiers

PMID37807827
PMCPMC10667795
OpenAlexW4387439238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.