Evidence map›Paper›PMID 37807790›Full record

Observational studyJournal of pediatric rehabilitation medicine2024

Physical activity and functional limitations in pediatric multiple sclerosis: Are fatigue and depression confounding variables?

E Morghen Sikes, Marcia Finlayson, Brenda Banwell, Ruth Ann Marrie, E Ann Yeh, Rob Motl

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric rehabilitation medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E Morghen SikesDivision of Occupational Therapy, Shenandoah University, Leesburg, VA, USA.
Marcia FinlaysonSchool of Rehabilitation Therapy, Queen's University, Kingston, ON, Canada.
Brenda BanwellDivision of Child Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ruth Ann MarrieDepartments of Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
E Ann YehDepartment of Pediatrics, Division of Neurology, Hospital for Sick Children, Toronto, ON, Canada.
Rob MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePediatric-onset multiple sclerosis (MS) is associated with risk for functional limitations defined as the perceived reduction in capacity for undertaking activities of daily living. Moderate-to-vigorous physical activity (MVPA) has been associated with less frequent and less impactful functional limitations, but the symptoms of fatigue and depression have not been considered as potential confounding variables. This study examined whether fatigue and depression confound the association between MVPA and functional limitations among youth with pediatric MS.

methodsParticipant data were accumulated from three ongoing observational studies. The combined sample included 65 cases of pediatric-onset MS (24 male/41 female, 16±1.7 years of age). Data on self-report MVPA, functional limitations, depression, and fatigue were analyzed.

resultsMVPA was significantly associated with functional limitations (

conclusionSelf-reported MVPA was associated with perceived functional limitations among youth with pediatric MS independent of perceived fatigue and depressive symptoms.

Indexed as

Activities of Daily LivingDepressionExerciseFatigueMultiple SclerosisAdolescentChildFemaleHumansMaleSelf Reportdepression.fatiguefunctional limitationsPediatric multiple sclerosisphysical activity

Identifiers

PMID37807790
PMCPMC13292620

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.