ArticleEuropean journal of nuclear medicine and molecular imaging2024
In vivo cerebral metabolic and dopaminergic characteristics in multiple system atrophy with orthostatic hypotension.
Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Brain Network Patterns in Patients With Multiple System Atrophy: Spatial Independent Component Analysis Using FDG-PET Data.Neurology · 2026Article
- Molecular imaging based spatiotemporal dynamics progression of brain glucose metabolism in multiple system atrophy.European journal of nuclear medicine and molecular imaging · 2026Article
- Identification of metabolic progression and subtypes in progressive supranuclear palsy by PET molecular imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism.Frontiers in aging neuroscience · 2025Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeMultiple system atrophy (MSA) is a rare neurodegenerative disease, often presented with orthostatic hypotension (OH), which is a disabling symptom but has not been very explored. Here, we investigated MSA patients with OH by using positron emission tomography (PET) with
methodsTotally, 51 patients with MSA and 20 healthy controls (HC) who underwent
resultsThe SPM results showed significant hypometabolism in the pons and right cerebellar tonsil, as well as hypermetabolism in the left parahippocampal gyrus and left superior temporal gyrus in MSA-OH(+) compared with MSA-OH(-). A reduced
conclusionIn this study, the changes in glucose metabolism in the pons, right cerebellar tonsil, left parahippocampal gyrus and left superior temporal gyrus were found closely related to OH in MSA patients. And the decreased presynaptic dopaminergic function in the left caudate may contribute to OH in MSA. Taken together, this study provided in vivo pathophysiologic information on MSA with OH from neuroimaging approach, which is essential for a better understanding of MSA with OH.
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Registered trials
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