Evidence map›Paper›PMID 37806974›Full record

ArticleClinical and experimental nephrology2024

Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.

Seigo Ito, Taro Misaki, Yasuyuki Nagasawa, Ryota Nomura, Shuhei Naka, Akiko Fukunaga, Daiki Matsuoka, Saaya Matayoshi, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

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Article in Clinical and experimental nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The Molecular Comorbidity Network of Periodontal Disease.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Seigo ItoDepartment of Internal Medicine, Japan Self-Defense Force Iruma Hospital, Iruma, Saitama, Japan.
Taro MisakiDivision of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan. misakitar@gmail.com.ORCID http://orcid.org/0000-0002-0476-2550
Yasuyuki NagasawaDepartment of General Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.
Shuhei NakaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Akiko FukunagaDivision of Dentistry, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Daiki MatsuokaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Saaya MatayoshiDepartment of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Michiyo Matsumoto-NakanoDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Kazuhiko NakanoDepartment of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Okayama University · JPThe University of Osaka · JPHiroshima University · JPHyogo Medical University · JPSeirei Christopher University · JPSeirei Hamamatsu General Hospital · JP

Funding

JSPS KAKENHI 19K10098JSPS KAKENHI 21H03149JSPS KAKENHI 21K08242JSPS KAKENHI 23K09146
6 · The paper itself

Abstract

backgroundThe relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)-particularly with respect to galactose-deficient IgA1 (Gd-IgA1)-has not been fully elucidated.

methodsSaliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group.

resultsCompared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05).

conclusionOur findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1.

Indexed as

Glomerulonephritis, IGARenal Insufficiency, ChronicGalactoseHumansImmunoglobulin AMouthPorphyromonas gingivalisGalactosegalactosyl-deficient IgA1Immunoglobulin ACnm-positive S. mutansDental cariesGalactose-deficient IgA1IgA nephropathyPeriodontal diseaseP. gingivalis

Identifiers

PMID37806974
OpenAlexW4387435396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.