Evidence map›Paper›PMID 37806114›Full record

ArticleTranslational oncology2023

Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.

Hao Wu, Yin Zhang, Jiawei Liang, Jianzhuang Wu, Yixuan Zhang, Haochen Su, Qiyue Zhang, Yonghua Shen, Shanshan Shen, Lei Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hao WuDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China; Department of Geriatrics, Nanjing Red Cross Hospital, No. 242, Baixia Road, Qinhuai District, Nanjing 21000 Jiangsu, PR China.
Yin ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Jiawei LiangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Jianzhuang WuInstitute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210033 Jiangsu, PR China.
Yixuan ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Haochen SuInstitute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China; Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008 Jiangsu, PR China.
Qiyue ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Yonghua ShenDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Shanshan ShenDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Lei WangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China.
Xiaoping ZouDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China; Department of Gastroenterology, Affiliated Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210023 Jiangsu, PR China.
Cheng HangDepartment of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, Taicang 215400 Jiangsu, PR China. Electronic address: hc5626@suda.edu.cn.
Shu ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China. Electronic address: zhangsgastro@nju.edu.cn.
Ying LvDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008 Jiangsu, PR China; Institute of Pancreatology, Nanjing University, Nanjing 210008 Jiangsu, PR China; Department of Gastroenterology, Affiliated Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210023 Jiangsu, PR China. Electronic address: lvying@njglyy.com.
Nanjing Drum Tower Hospital · CNChina Pharmaceutical University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium compounds, a classic class of metal complex medicine that target GSK 3β and are widely known as mood-stabilizer, have recently been reported as potential anti-tumor drugs. The objective of this investigation was to explore the anticancer potential of lithium chloride (LiCl) and elucidate its mode of action in pancreatic cancer cells. The MTT, colony formation, and Edu assay were used to evaluate the impact of LiCl on pancreatic cancer cell proliferation. Various methods were employed to investigate the anti-tumor activity of LiCl and its underlying mechanisms. Cell cycle analysis and apoptosis detection assays were utilized for in vitro experiments, while the orthotopic pancreatic cancer mouse model was employed to evaluate the effectiveness of LiCl treatment in vivo. Furthermore, the impact of LiCl on the proliferation of patient-derived organoids was also studied. The results demonstrated that LiCl inhibited the proliferation of pancreatic cancer (PC) cells, induced G2/M phase arrest, and activated apoptosis. Notably, the triggering of endoplasmic reticulum (ER) stress by LiCl was observed, leading to the activation of the PERK/CHOP/GADD34 pathway, which subsequently promoted apoptosis in PC cells. In the future, Lithium compounds could become an essential adjunct in the treatment of human pancreatic cancer.

Indexed as

LithiumNatural medicinePancreatic cancerTargeted therapy

Identifiers

PMID37806114
PMCPMC10579530
OpenAlexW4387427277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.