ArticleCell reports2023
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity.
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Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Harnessing exosomes in dry eye disease: a triple threat approach.BMC ophthalmology · 2026Pooled it
- Systemic health impact of cancer-associated extracellular vesicles and particles.Nature reviews. Cancer · 2026Review
- miR-27b-5p targets RAB27A to regulate exosome secretion and migration of pancreatic cancer cells.Translational cancer research · 2026Article
- Noncoding SNP rs17728461 modulates lung cancer progression via interchromosomal regulation of RAB27A expression.Oncogene · 2026Article
- Exosome-loaded nanoradiosensitizers in radiotherapy for preventing post-irradiation tumor recurrence: mechanisms, preclinical evidence, and translational challenges.Discover nano · 2026Review
- Exosomes from tumor-associated macrophages promote glycolysis and malignant NSCLC progression by delivery of hsa_circ_0000896.Biology direct · 2026Article
- Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1.British journal of cancer · 2026Article
- Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma.Clinical and translational medicine · 2026Review
- The neuro-vascular-immune triad: the interactive network in the tumor microenvironment.Cell communication and signaling : CCS · 2026Review
- Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2.Cell death & disease · 2026Article
- Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer.Molecular medicine (Cambridge, Mass.) · 2026Article
- Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer.Signal transduction and targeted therapy · 2026Article
- Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies.Clinical and experimental immunology · 2026Review
- Research progress on the roles of extracellular vesicles in tumor immunity and drug resistance.Frontiers in immunology · 2026Review
- Review
- Research Progress of Multicomponent Co-Loaded Nanomedicine Delivery Systems for Tumor Immunotherapy.International journal of nanomedicine · 2026Review
- CLEVER-1Frontiers in immunology · 2026Review
- Role of elevation of glycolysis in tumor-associated macrophages in glioblastoma immune evasion and therapeutic implications.PNAS nexus · 2026Review
- Polarization-Specific Macrophage-Derived Extracellular Vesicles: Molecular Cargo, Tumor Microenvironment Remodeling, and Therapeutic Opportunities.International journal of nanomedicine · 2026Review
- The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model.PLoS biology · 2026Article
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 1 country.
Wenqun ZhongDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Youtao LuDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xuexiang HanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jingbo YangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhiyuan QinDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei ZhangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ziyan YuDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bin WuDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shujing LiuAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei XuAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cathy ZhengAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lynn M SchuchterAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Giorgos C KarakousisDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tara C MitchellAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ravi AmaravadiAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ahron J FlowersDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Phyllis A GimottyAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Min XiaoMolecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, PA 19104, USA.
Gordon MillsDivision of Oncological Science, School of Medicine, and Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA.
Meenhard HerlynMolecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, PA 19104, USA.
Haidong DongDepartments of Urology and Immunology, Mayo College of Medicine and Science, Rochester, MN 55905, USA.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Junhyong KimDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xiaowei XuAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei GuoDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: guowei@sas.upenn.edu.
University of Pennsylvania · USThe Wistar Institute · USMayo Clinic · USOregon Health & Science University · US
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Jozef Madzo · 1985 to 2026
$75.9MTargeting exosomal PDL1 to improve immunotherapyP50CA261608 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2021 to 2025
$11.3MTargeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1MMolecular Basis and Regulatory Mechanisms of Exosome SecretionR35GM141832 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WEI GUO · 2021 to 2026
$3.9MTargeting stem-like cells and their niche in pancreatic cancerR37CA244911 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Tuomas Tammela · 2020 to 2026
$3.4MA data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4MModular approach for the delivery of antibodies into the cytoplasm of cellsR01CA241661 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2019 to 2023
$1.8MTargeting dual functions of PD-L1 for cancer therapyR01CA256927 · NCI · MAYO CLINIC ROCHESTER · PI DONG, HAIDONG · 2021 to 2025
$1.8MNCATS NIH HHS DP2 TR002776NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA174523NCI NIH HHS P50 CA261608NCI NIH HHS R01 CA241661NCI NIH HHS R01 CA256927NCI NIH HHS R37 CA244911NIGMS NIH HHS R35 GM141832
Abstract
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of macrophages to tumor-associated macrophages (TAMs) promotes the secretion of exosomes. Mechanistically, increased exosome secretion is driven by MADD, which is phosphorylated by Akt upon TAM induction and activates Rab27a. TAM exosomes carry high levels of programmed death-ligand 1 (PD-L1) and potently suppress the proliferation and function of CD8
Indexed as
ExosomesMelanomaAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesCell Line, TumorHumansMiceRNA, Small InterferingTumor-Associated MacrophagesTumor MicroenvironmentUp-RegulationB7-H1 AntigenRNA, Small InterferingCP: CancerCP: Immunologyexosomeimmunotherapyprogrammed cell death ligand 1tumor-associated macrophages
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.