ArticleAnnals of Saudi medicine
Evaluation of the systemic immune inflammation index and the systemic inflammatory response index as new markers for the diagnosis of acute appendicitis in children.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Blood biomarkers and penalized logistic regression for the prediction of complicated appendicitis in children: a retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Autism Spectrum Disorder and Cardiovascular Risk: The Role of Frontal QRS-T Angle and Systemic Immune-Inflammation Index.Psychiatry investigation · 2026Article
- Diagnostic Accuracy of Inflammatory Biomarkers in Differentiating Acute Appendicitis From Other Acute Abdomen and Predicting Disease Severity: A Prospective Comparative Cross-Sectional Study.Health science reports · 2026Article
- The role of the HALP score and inflammatory biomarkers in differentiating complicated and uncomplicated acute appendicitis: a retrospective cohort study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Diagnostic and prognostic utility of SIRI and CAR in necrotizing fasciitis: a retrospective cohort study on disease severity and clinical outcomes.European journal of medical research · 2026Article
- Development and validation of a diagnostic nomogram based on peripheral blood composite inflammatory markers for complicated acute appendicitis: a retrospective study.Frontiers in surgery · 2026Article
- Evaluation of inflammatory markers in pediatric patients with otitis media with effusion: a retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
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- Evaluation of computed tomography (CT) appendicitis score and laboratory parameters in acute appendicitis with and without CT-detected appendicolith.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Association Between Allergic Rhinitis and Children With Appendectomy-A Nationwide Population-Based Retrospective Cohort Study.Health science reports · 2025Article
- Outcomes of inflammatory markers in the diagnosis of complicated rhinosinusitis in children.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- PAN-Immune inflammation value: a new biomarker for diagnosing appendicitis in children??BMC pediatrics · 2025Article
- Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis.Scientific reports · 2025Article
- Article
- The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study.Life (Basel, Switzerland) · 2024Article
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6 authors.
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Abstract
backgroundAbdominal pain is a common and non-specific symptom in children. It is important to be able to distinguish the source of abdominal pain before surgery.
objectivesAssess importance of the systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and other systemic inflammatory response blood cell indices in predicting the diagnosis and prognosis of acute appendicitis in children.
designRetrospective cohort
settingSingle center in Turkey PATIENTS AND
methodsThe files of patients with abdominal pain aged 0-18 years who underwent surgery for appendicitis in our clinic between January 2011 and January 2022 were reviewed. According to the pathology results, patients were divided into two groups, those with pathologic findings of appendicitis (positive for appendicitis) and those without appendicitis. Systemic inflammation markers were statistically compared between the groups.
main outcome measuresSystemic inflammation markers. SAMPLE SIZE: 1265 patients
resultsOf the 1265 patients, 784 (62%) were male and 481 were female (38%). According to the pathologic examinations, 256 (20.2%) patients did not have appendicitis, and 1009 (79.8%) patients had acute appendicitis. The SIRI level was significantly higher in patients with acute appendicitis compared with patients without acute appendicitis (
conclusionIn children presenting with abdominal pain, high SIRI and SII values alone support the diagnosis of acute appendicitis at a rate of 95%. When physical examination findings, duration of pain, and imaging test results are added, the diagnosis becomes clear at a rate of 98%. LIMITATIONS: Single-center study and retrospective.
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