ArticleMolecular autism2023
EEG functional connectivity in infants at elevated familial likelihood for autism spectrum disorder.
Article in Molecular autism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Alterations in Multidimensional Functional Connectivity Architecture in Preschool Children with Autism Spectrum Disorder.Brain sciences · 2026Article
- Sex differences in early brain development in a multi-site ASD likelihood cohort.Frontiers in computational neuroscience · 2026Article
- EEG neurosubtyping of infants predicts language trajectories.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- The Development of Lateralized Brain Oscillations in Infants: Lessons From Autism.Developmental psychobiology · 2025Article
- Theta and alpha connectivity in children with autism spectrum disorder.Brain communications · 2025Article
- Enhancing autism spectrum disorder classification in children through the integration of traditional statistics and classical machine learning techniques in EEG analysis.Scientific reports · 2023Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundMany studies have reported that autism spectrum disorder (ASD) is associated with atypical structural and functional connectivity. However, we know relatively little about the development of these differences in infancy.
methodsWe used a high-density electroencephalogram (EEG) dataset pooled from two independent infant sibling cohorts, to characterize such neurodevelopmental deviations during the first years of life. EEG was recorded at 6 and 12 months of age in infants at typical (N = 92) or elevated likelihood for ASD (N = 90), determined by the presence of an older sibling with ASD. We computed the functional connectivity between cortical sources of EEG during video watching using the corrected imaginary part of phase-locking values.
resultsOur main analysis found no significant association between functional connectivity and ASD, showing only significant effects for age, sex, age-sex interaction, and site. Given these null results, we performed an exploratory analysis and observed, at 12 months, a negative correlation between functional connectivity and ADOS calibrated severity scores for restrictive and repetitive behaviors (RRB). LIMITATIONS: The small sample of ASD participants inherent to sibling studies limits diagnostic group comparisons. Also, results from our secondary exploratory analysis should be considered only as potential relationships to further explore, given their increased vulnerability to false positives.
conclusionsThese results are inconclusive concerning an association between EEG functional connectivity and ASD in infancy. Exploratory analyses provided preliminary support for a relationship between RRB and functional connectivity specifically, but these preliminary observations need corroboration on larger samples.
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