ArticleNature communications2023
Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- miRNAs as potential biomarkers for early detection of prediabetes among obesity: a systematic review.Bioscience reports · 2025Pooled it
- Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults.Cell reports. Medicine · 2026Observational
- Stage-specific temporal associations between body mass index trajectories and Alzheimer's disease pathologies.European radiology · 2026Article
- Identifying Predictors of Weight-Related Outcomes With Fixed-Dose, Extended-Release Naltrexone and Bupropion Among Treatment-Adherent Patients in Phase 3 COR Trials: A Treatment Target Analysis.Obesity science & practice · 2026Article
- Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health.Nature communications · 2026Article
- Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors.Pediatric research · 2026Article
- Article
- Weight-adjusted-waist index as a mediator in the association between atherogenic index of plasma and obstructive sleep apnoea: insights from NHANES 2015-2020.Journal of health, population, and nutrition · 2026Article
- Assessment of MRI-Derived proton density fat fraction of total subcutaneous adipose tissue for discrimination primary aldosteronism subtypes.Endocrine · 2026Article
- Multi-omic definition of metabolic obesity through adipose tissue-microbiome interactions.Nature medicine · 2026Article
- Effects of timing and eating duration of time restricted eating on metabolic outcomes: systematic review and network meta-analysis.BMJ medicine · 2026Article
- Association between different metabolic obesity phenotypes and hyperuricemia: the modifying role of liver enzymes.Frontiers in public health · 2026Article
- Predicting metabolic syndrome in adolescents from device-measured 24-h movement behaviors: a machine learning approach.Frontiers in public health · 2026Article
- Metabolic risk stratification and psychotic symptoms in first-episode drug-naïve major depressive disorder: a principal component-based cross-sectional study.Frontiers in psychiatry · 2026Article
- Elevated body mass index as a prognostic marker in acute liver failure: Implications from a two-decade cohort.World journal of clinical cases · 2025Article
- Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort.The American journal of clinical nutrition · 2025Article
- Evolving perspectives on evaluating obesity: from traditional methods to cutting-edge techniques.Annals of medicine · 2025Review
- Beyond BMI: Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine.Diagnostics (Basel, Switzerland) · 2025Review
- The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls.Journal of neurochemistry · 2025Article
- Precision Medicine for Obesity Treatment.Journal of the Endocrine Society · 2025Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic disorders giving rise to the concept of "metabolically healthy obese". We use lipidomic-based models for BMI to calculate a metabolic BMI score (mBMI) as a measure of metabolic dysregulation associated with obesity. Using the difference between mBMI and BMI (mBMIΔ), we identify individuals with a similar BMI but differing in their metabolic health and disease risk profiles. Exercise and diet associate with mBMIΔ suggesting the ability to modify mBMI with lifestyle intervention. Our findings show that, the mBMI score captures information on metabolic dysregulation that is independent of the measured BMI and so provides an opportunity to assess metabolic health to identify "at risk" individuals for targeted intervention and monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.