ArticleNature communications2023
Immediate neural impact and incomplete compensation after semantic hub disconnection.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Immediate to longer-term neurophysiological impact of acute neural network disruption.medRxiv : the preprint server for health sciences · 2026Article
- From Senses to Memory During Childhood: A Systematic Review and Bayesian Meta-Analysis Exploring Multisensory Processing and Working Memory Development.European journal of investigation in health, psychology and education · 2025Review
- A left-lateralized dorsolateral prefrontal network for naming.Cell reports · 2025Article
- Automated generation of epilepsy surgery resection masks: The RAMPS pipeline.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Drawing from name in semantic dementia reveals graded object knowledge representations in anterior temporal lobe.Memory & cognition · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversial. We report intracranial recordings from two patients during a speech prediction task, obtained minutes before and after neurosurgical treatment requiring disconnection of the left anterior temporal lobe (ATL), a candidate semantic knowledge hub. Informed by modern diaschisis and predictive coding frameworks, we tested hypotheses ranging from solely neural network disruption to complete compensation by the indirectly affected language-related and speech-processing sites. Immediately after ATL disconnection, we observed neurophysiological alterations in the recorded frontal and auditory sites, providing direct evidence for the importance of the ATL as a semantic hub. We also obtained evidence for rapid, albeit incomplete, attempts at neural network compensation, with neural impact largely in the forms stipulated by the predictive coding framework, in specificity, and the modern diaschisis framework, more generally. The overall results validate these frameworks and reveal an immediate impact and capability of the human brain to adjust after losing a brain hub.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.